夫精宫腔内人工授精手术时机和妊娠相关性分析  

Analysis of Correlation between Surgical Timing and Pregnancy Outcomes of Intrauterine Artificial Insemination

作　　者：李斯晨[1] 吴乙璇[1] 刘见桥[1] 张伟良[1] 

机构地区：[1]广州医科大学附属第三医院生殖医学中心,广东省生殖医学重点实验室,广州510515

出　　处：《国际生殖健康／计划生育杂志》2016年第6期463-465,共3页Journal of International Reproductive Health/Family Planning

摘　　要：目的：探讨夫精宫腔内人工授精（IUI）时机及次数与妊娠率的关系。方法：回顾性分析851对在广州医科大学附属第三医院行夫精IUI治疗的不孕夫妇（共1 751个周期）,根据手术时机及次数,分为排卵前1次IUI、排卵后1次IUI、排卵前2次IUI、排卵前后各1次IUI 4组,比较4组妊娠率的差异。结果：排卵前、后行单次IUI组的妊娠率分别为11.21%和12.23%;排卵前行单次IUI后有排卵组妊娠率显著高于无排卵组（P〈0.05）。排卵前后各行1次IUI、排卵前行2次IUI妊娠率分别为16.21%和15.65%;排卵前行2次IUI后有排卵组临床妊娠率（17.14%）高于无排卵组（0.00%）,差异有统计学意义（确切概率法P=0.040）。有排卵周期中,排卵前1次、排卵后1次、排卵前2次、排卵前后各1次IUI的临床妊娠率分别为10.99%、12.23%、17.14%、16.21%,行2次IUI组的妊娠率虽然高于行1次IUI组,但差异无统计学意义（P〉0.05）。结论：只要确定卵泡破裂,排卵前后行IUI、行1次或2次IUI妊娠率无差异;但IUI后卵泡无破裂,则妊娠率为0-2.85%,因此针对2个周期IUI出现未破裂卵泡黄素化综合征者建议转行体外受精。Objective： To investigate the correlation between the surgical timing of insemination and thepregnancy rate of intrauterine artificial insemination （IUI）. Methods： The retrospective analysis was designed in 851 infertile couples with male factors who were treated with IUI （a total of 1 751 cycles）. Those cycles were divided into four groups as follows： Group 1 was one time of IUI before ovulation, Group 2 was one time of IUI after ovulation, Group 3 was two times of IUI before ovulation, and Group 4 was two times of IUI before and after ovulation individually. The pregnancy rates of four groups were then compared accordingly. Results： The pregnancy rates in group 1 and group 2 were 11.21% and 12.23%, while in group 1 the pregnancy rate in couples with ovulation after IUI was significantly higher than that in those couples with anovulation （P〈0.05） . The pregnancy rates in group 3 and group 4 were 16.21% and 15.65%, while in group 3 the pregnancy rate in couples with ovulation after IUI was significantly higher than that in those couples with anovulation （17.14% vs. 0.00%, P= 0.040）. In the ovulatory cycles of four groups, the pregnancy rates were 10.99%, 12.23%, 17.14% and 16.21% respectively （P〉0.05）. The pregnancy rate of two times of IUI was higher than that of one time of IUI （although P〉0.05）. Conclusions： There are not significant difference in the pregnancy rate in those couples with ovulation before or after IUI treatment, 1 or 2 times of IUI. However, the pregnancy rate is very low in those couples without ovulation before or after IUI treatment （0-2.85%）. Those women with the luteinized unruptured follicle syndrome （LUFS） during two cycles of IUI should be advised to treat with in vitro fertilization （IVF）.

关 键 词：授精 人工 授精 人工(丈夫供体) 妊娠率 子宫 

分 类 号：R714.8[医药卫生—妇产科学]