Wnt/β-catenin信号通路激活与宫颈病变研究新进展  

The Activated Wnt/β-catenin Pathway and Cervical Lesions

作　　者：乔迪[1] 宋静慧[1] 

机构地区：[1]内蒙古医科大学附属医院妇产科,呼和浩特010059

出　　处：《国际生殖健康／计划生育杂志》2016年第6期510-514,共5页Journal of International Reproductive Health/Family Planning

基　　金：国家自然学基金项目(81560243)

摘　　要：Wnt/β-catenin通路是经典的Wnt通路,作为细胞间信号转导通路之一,调控细胞增殖、分化、黏附及凋亡等,在胚胎发育过程中发挥重要作用。Wnt信号通路的异常激活可引起细胞异常增殖、分化而导致肿瘤的发生。此外,Wnt信号通路也是诱导肿瘤细胞发生上皮间质转化(EMT)过程的关键通路之一,从而影响肿瘤的进展和转移。该通路中包含许多信号成员蛋白,其中E钙黏蛋白(E-cadherin)和β-连环素(β-catenin)是该通路的核心因子,并且是构成上皮细胞间连接复合体的关键分子。E-cadherin表达下调和β-catenin表达异位可激活Wnt通路的靶基因,通过降低上皮细胞间的黏附力、增加细胞的增殖及迁移能力,促使上皮细胞发生间质转化。综述Wnt/β-catenin通路激活上皮间质转化的过程及二者与宫颈癌的发生、进展及转归的相关性。Wnt/β -catenin pathway, the classic Wnt pathway, regulates the cell proliferation, differentiation, adhesion and apoptosis. As one of the intercellular signal transduction pathways, Wnt/β-catenin pathway also plays an important role in embryonic development. Aberrant activation of the Wnt signaling pathway can lead to abnormal cell proliferation and differentiation, and cancer. In addition, Wnt signaling pathway is also one of the key pathways induced the epithelial-mesenchymal transformation （EMT） of tumor cells, which thereby affect tumor progression and metastasis. There are many factors in this pathway, including those core factors such as E-cadherin and P-catenin. E- cadherin and P-catenin are two key proteins in the junction complex to form adhesion between epithelial cells. The down-regulated E-cadherin and the ectopic expression of P-catenin can activate those target genes of the Wnt pathway, which promotes the transformation of epithelial cells by reducing the adhesion as well as increasing proliferation and migration of epithelial cells. This paper reviewed the research progress on the Wnt/β -catenin pathway activation and the EMT, as well as the related mechanism and clinical outcomes of cervical lesions.

关 键 词：WNT蛋白质类 Β连环素 钙黏着糖蛋白类 宫颈疾病 信号通路 上皮间质转化 

分 类 号：R711.74[医药卫生—妇产科学]