延长聚乙二醇化干扰素疗程治疗HBsAg和HBsAb双阳性慢性乙型肝炎一例  

A case of prolongable curative course by Peg IFN on treating chronic hepatitis B with positive HBsAg and HBsAb

作　　者：陈铿[1] 应若素[1] 刘惠媛[1] 

机构地区：[1]广州市第八人民医院肝病科,广州市510060

出　　处：《中华实验和临床感染病杂志（电子版）》2016年第4期510-512,共3页Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)

摘　　要：目的通过对HBsAg和HBsAb双阳性慢性乙型肝炎患者干扰素治疗病例进行回顾性总结,为临床诊疗提供帮助。方法回顾性分析患者的临床资料、诊治经过和实验室资料。结果患者的聚乙二醇化干扰素疗程延长至108周,实现了停药后持久的HBs Ag清除。结论在精准的乙型肝炎病毒学、血清学检测引导下,延长干扰素抗病毒疗程,有望达到慢性乙型肝炎理想的治疗终点。Objective To provide better diagnosis and therapy through a retrospective summary of chronic hepatitis B patient with positive HBs Ag and HBs Ab after interferon therapy. Methods The clinical data, treatment and laboratory findings of the patient were analyzed retrospectively. Results The sustained HBs Ag loss is achieved after discontinuing therapy when the period of Peg-IFN treatment is extended to 108 weeks. Conclusions The treatment of chronic hepatitis B is expected to achieve the ideal end point by extending the period of interferon therapy under the guidance of accurate virological and serological detection.

关 键 词：肝炎 乙型 慢性 干扰素 突变 病例报告 

分 类 号：R512.62[医药卫生—内科学]