CD64与降钙素原对骨折患者术后感染早期诊断的应用价值  

Application value of CD64 index and Procalcitonin in the early diagnosis of postoperative infection in fracture patients

作　　者：农贤刚[1] 

机构地区：[1]广西壮族自治区贵港市中西医结合骨科医院,537100

出　　处：《国际检验医学杂志》2016年第22期3147-3148,3152,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨中性粒细胞CD64与降钙素原(PCT)对骨折患者术后感染早期诊断的临床价值。方法选取2012年5月至2015年5月开放性骨折并实施手术治疗患者80例,将其分为感染组(37例)和未感染组(43例),2组均于术后1、3、5、7d采集静脉血检测CD64和PCT水平,评价2种指标在骨折术后感染诊断中的敏感性及特异性。结果术后1d,感染组CD64显著高于未感染组,差异有统计学意义(P<0.05),与未感染组比较,PCT水平差异无统计学意义(P>0.05);感染组CD64和PCT水平在术后3d达到高峰,术后3、5、7d水平均显著高于未感染组,差异有统计学意义(P<0.05);CD64诊断敏感性及特异性均高于PCT。结论 CD64和PCT测定均有助于骨折术后感染的早期诊断。Objective To explore the clinical value of neutrophil CD64 index and Procalcitonin（PCT）in early diagnosis.of postoperative infection in patients with fracture.Methods Totally 80 open fracture patients who received surgical treatment form May2012 to May 2015 were enrolled in the study and divided into the infection group with 37 cases and the non infection group with 43 cases.The levels of CD64 and PCT were detected on postoperative 3,5and 7dby collecting the venous blood in the group,and their sensitivity and specificity for diagnosing postoperative infection in patients with bone fracture were evaluated.Results On day 1after the surgeries,CD64 index in infection group was significantly higher than that in non infection group（P〈0.05）,however,there was no significant difference in the level of PCT between the infection group and the non infection group（P〉0.05）;The levels of CD64 and PCT in infection group arrived at a peak on the third day,levels on postoperative 3,5and 7dwere significantly higher than that in non infected group,there were significant differences（P〈0.05）;The sensitivity and specificity of CD64 in diagnosis of the postoperative infections were higher than those of the PCT.Conclusion The determination of the levels of both PCT and CD64 index is conducive to the early diagnosis of postoperative infection in fracture patients.

关 键 词：骨折 感染 CD64指数 降钙素原 

分 类 号：R687.3[医药卫生—骨科学] R446.1[医药卫生—外科学]