N-乙酰基-5-甲氧基色胺的化学合成  

Chemical Synthesis of Melatonin

作　　者：胡松林 蔡瑾 须辑 

机构地区：[1]罗田县新普生药业有限公司,湖北罗田438600 [2]上海市退(离)休高级专家协会化工冶金专业委员会,上海201601

出　　处：《化学世界》2016年第11期699-702,共4页Chemical World

摘　　要：综合国内外大量文献,简单介绍N-乙酰基-5-甲氧基色胺(褪黑素)的化学合成的理化性质、生理活性、用途和化学合成工艺路线,并提出了一条以丙二酸二乙酯和丙烯腈为起始原料的适合工业生产的简便、经济的化学合成方法,该工艺具有原料易得、反应条件温和、质量好和收率高等特点。The physico-chemical properties biological activity and uses and chemical synthetic technology of melatonin were introduced.A simple and economical industrial chemical synthetic method using diethyl malonate and acrylonitrile as starting raw materials was presented.In this method,the raw materials are easily obtainable,and the reaction conditions are mild.The quality of the product is good,and high yield can be obtained.

关 键 词：N-乙酰基-5-甲氧基色胺 2-氰乙基丙二酸二乙酯 3-乙氧甲酰-2-哌啶酮 2.3-哌啶二酮-3-(4′-甲氧基)苯腙 1.2.3.4-四氢-6-甲氧基-1-氧代-β-咔啉 2-羧基-5-甲氧基色胺 5-甲氧基色胺 

分 类 号：O641.4[理学—物理化学]