急性冠脉综合征和急性主动脉夹层患者外周血TSP-1和D-dimer水平比较研究  

Comparative Study of TSP-1 and D-dimer Levels in Peripheral Blood of Patients with Acute Coronary Syndrome and Acute Aortic Dissection

作　　者：肖子亚 薛渊[1] 顾国嵘[1] 王豪俊 栾骁[1] 尹俊[1] 宋振举[1] 施东伟[1] 童朝阳[1] 姚晨玲[1] 

机构地区：[1]复旦大学附属中山医院,上海200032

出　　处：《中国医学创新》2016年第32期25-27,共3页Medical Innovation of China

基　　金：上海市科学技术委员会资助项目(114119a9000)

摘　　要：目的:探讨凝血酶敏感蛋白-1(thrombospondin-1,TSP-1)和D-二聚体(D-dimer)联合检测对急性冠脉综合征(acute coronary syndrome,ACS)和急性主动脉夹层(acute aortic dissection,AAD)患者的鉴别诊断价值。方法:收集ACS组患者120例、AAD组患者120例和正常对照组60例,取血清,分别检测TSP-1和D-dimer在三组中的血清水平,并对结果进行分析。结果:TSP-1和D-dimer在ACS组、AAD组浓度均高于正常对照组(P<0.05),而TSP-1在ACS组升高更明显,D-dimer在AAD组升高更明显。结论:TSP-1和D-dimer联合检测可以协助ACS和AAD这两种疾病的鉴别诊断。Objective： To investigate the value of combined detection of thrombospondin-1 （ TSP-1 ） and D-dimer in the differential diagnosis of acuie coronary syndrome （ ACS ） and acute aortic dissection （ AAD ） patients.Method： Serum of 120 patients with ACS, 120 patients with AAD and 60 healthy people were coUeeted. The serum levels of TSP-1 and D-dimer in three groups were detected respectively, and the results were analyzed. Result： The levels of TSP-1 and D-dimer were higher in ACS group and AAD group than those of normal control group （ P〈0.05 ）, and TSP-1 was more remarkably in ACS group while D-dimer was more remarkably in AAD group.Conclusion： Combined detection of TSP-1 and D-dimer can help to identify ACS and AAD.

关 键 词：急性冠脉综合征 急性主动脉夹层 凝血酶敏感蛋白-1 D-二聚体 

分 类 号：R541.4[医药卫生—心血管疾病] R543.1[医药卫生—内科学]