地特胰岛素对2型糖尿病患者人体成分的影响  

Effect of Once-daily Insulin Detemir on Body Composition in Poorly Controlled Type 2 Diabetes Patients Treated with Oral Antidiabetic Drugs

作　　者：朱珠[1] 罗兰[1] 卢林娜[1] 高政南[1] 

机构地区：[1]大连医科大学附属大连市中心医院,辽宁大连116033

出　　处：《中国医学创新》2016年第32期32-35,共4页Medical Innovation of China

摘　　要：目的：评价口服降糖药控制不佳的2型糖尿病患者加用地特胰岛素对人体成分的影响。方法：选取2010年2-9月大连市中心医院就诊的27例口服降糖药控制不佳的2型糖尿病患者（均符合1999年WHO的糖尿病诊断标准）,在原有治疗方案的基础上加用地特胰岛素6-8 U/d起始治疗,治疗期为3个月,治疗前后分别应用Inbody 720人体成分分析仪进行人体成分分析,同时测定27例患者治疗前后身高、体重、糖化血红蛋白等,并比较治疗前后相关指标的变化。结果：治疗3个月后患者Hb A1c较前明显下降,差异有统计学意义（t=5.116,P〈0.001）。治疗3个月后体脂百分数较前下降,差异有统计学意义（t=2.161,P〈0.05）。治疗3个月后体重、BMI、腰臀比、蛋白质、无机盐、脂肪量、肌肉量、内脏脂肪面积等与治疗前相比,差异均无统计学意义（P〉0.05）。结论：对口服药控制不佳的2型糖尿病患者加用地特胰岛素治疗,在血糖明显下降的同时,体重呈下降趋势,其中肌肉量无明显变化,但体脂肪比例明显下降。Objective： To evaluate the effect of once-daily Insulin Detemir on the body composition in poorly controlled type 2 diabetes patients treated with oral antidiabetic drugs.Method： A total of 27 cases type 2 diabetes patients with poor glycemic control by oral antidiabetic drugs were added to receive once-daily bedtime Insulin Detemir injection.The observation lasted for 3 months.The parameters of the body composition were measured before and after treatment by Inbody 720 body composition analyzer.The parameters included height weight and HbA1 e also were measured before and after treatment.Result： After 3 months of treatment, HbA 1 c was significantly decreased than before treatment （t=5.116, P〈0.001 ） .After 3 months of treatment, the percentage of fat was significantly decreased than before treatment （ t=2.161, P〈0.05 ） .Conclusion： Once-daily Insulin Detemir added to oral antidiabetic drugs in poorly controlled type 2 diabetes patients can improve glycemic control. At the same time weight on a downward trend which muscles no obvious changes, but fat ratio declined markedly.

关 键 词：2型糖尿病 地特胰岛素 人体成分 

分 类 号：R587.1[医药卫生—内分泌]