细胞外囊泡在心血管疾病中的研究进展  

Research Progress on Extracellular Vesicle in Cardiovascular Disease

作　　者：陈科辉 郭润民 梁伟钧 

机构地区：[1]广东医科大学附属医院,广东湛江524001

出　　处：《中国医学创新》2016年第32期140-144,共5页Medical Innovation of China

基　　金：广东省科技计划项目(20110316)

摘　　要：最近,细胞外囊泡已成为在细胞生物学和生物医学公认的重要成员。细胞外囊泡包括外泌体、微粒和凋亡小体,大多数分泌细胞中含有磷脂双分子层结构。重要的是,越来越多的证据支持细胞外囊泡可以作为在人类疾病中的生物标志物,治疗靶点或工具。心血管疾病无疑是其中最热门和快速增长的细胞外囊泡研究领域。然而,在有关不同的心血管疾病研究中,细胞外囊泡有时可以发挥不同的生物效应。因此,这些囊泡到底对心血管健康是有益或有害似乎还存在疑问。在这篇综述,笔者将介绍细胞外囊泡和概述其在心血管疾病的生物学作用。Recently, extraeellular vesicle plays a crucial role in both physiology and pathology. Extracellular vesicles, including exosomes, micropartic]es and apoptotic bodies, and most of the secretory cells contain phospholipid bilayer structure.Importantly, a growing bocly of evidence to support the extracellular vesicles can be used as a biomarker, therapeutic targets or tools in human disease.Cardiovascular disease is one of the most popular research areas and the rapid growth of extracellular vesicles.However, in the different cardiovascular disease study, extraeellular vesicles can sometimes play a different biological effects.As a result, these vesicles what is beneficial or harmful to cardiovascular health, it seems, are still in doubt.In this review, we will introduce the extracellular vesicles and summarize its biological role in cardiovascular disease.

关 键 词：细胞外囊泡 外泌体 微粒 心血管疾病 MICRORNA 

分 类 号：R54[医药卫生—心血管疾病]