缬沙坦氨氯地平治疗肾综合征出血热急性肾衰竭效果研究  

Research of effect by valsartan amlodipine in the treatment of hemorrhagic fever with renal syndrome acute renal failure

作　　者：刘玉柱[1,2] 陈可彬 吴玮[3] LIU Yu-zhu CHEN Ke-bin WU Wei(Shandong Medical school of Qingdao Hospital, Qingdao 273400, Chin)

机构地区：[1]山东青岛大学医学院,266003 [2]山东省费县人民医院 [3]山东青岛市传染病医院

出　　处：《中国实用医药》2016年第29期1-3,共3页China Practical Medicine

摘　　要：目的探讨缬沙坦氨氯地平治疗肾综合征出血热急性肾衰竭的临床效果。方法 120例急性肾衰竭并肾综合征出血热的患者,随机分为缬沙坦组、氨氯地平组、缬沙坦氨氯地平组,各40例,分别给予缬沙坦、氨氯地平、缬沙坦氨氯地平片治疗。观察比较三组患者治疗前后24 h尿量、血钾、尿微量清蛋白(m ALB)、血清肌酐(Scr)水平等指标,以及足踝部水肿发生情况。结果三组患者治疗前24 h尿量、血钾、尿m ALB、Scr水平比较差异无统计学意义(P>0.05),三组患者治疗后24 h尿量、血钾、尿m ALB、Scr水平均较本组治疗前明显改善,差异有统计学意义(P<0.05),缬沙坦氨氯地平组24 h尿量、血钾、尿m ALB、Scr水平改善情况优于其他两组,差异有统计学意义(P<0.05)。本次治疗以足裸部水肿为主要不良反应,缬沙坦组足裸部水肿发生率为2.5%、缬沙坦氨氯地平组为32.5%,均明显低于氨氯地平组的67.5%,差异有统计学意义(P<0.05)。结论缬沙坦氨氯地平能够有效缓解肾综合征出血热急性肾衰竭患者的临床症状,促进排尿,缓解水肿,减轻患者病痛,值得在临床推广。Objective To investigate clinical effect by valsartan amlodipine in the treatment of hemorrhagic fever with renal syndrome acute renal failure. Methods A total of 120 patients with acute renal failure and complicated hemorrhagic fever with renal syndrome were randomly divided into valsartan group, amlodipine group and valsartan amlodipine group, with 40 cases in each group. Three groups received respectively therapy by valsartan, amlodipine and valsartan amlodipine. Observation and comparison were made on 24 h urine volume, serum potassium, urine microalbumin（m ALB）, serum creatinine（Scr） levels and ankle edema before and after treatment in three groups. Results There was no statistically significant difference of 24 h urine volume, serum potassium, urine m ALB and Scr levels in the three groups before treatment（P〉0.05）. After treatment, all groups had much better 24 h urine volume, serum potassium, urine m ALB and Scr levels than those before treatment, and the difference had statistical significance（P〈0.05）. Valsartan amlodipine group had better improvement of 24 h urine volume, serum potassium, urine m ALB and Scr levels than the other two groups, and their difference had statistical significance（P〈0.05）. As the main adverse reaction, ankle edema showed incidence as 2.5% in valsartan group and 32.5% in valsartan amlodipine group, which were much lower than 67.5% in amlodipine group. The difference had statistical significance（P〈0.05）. Conclusion Valsartan amlodipine can effectively relieve clinical symptom of hemorrhagic fever with renal syndrome acute renal failure patients. This method accelerates urination, relieve edema and relieve pain in patients. It is worth clinical promotion.

关 键 词：缬沙坦氨氯地平 肾综合征出血热 急性肾衰竭 临床效果 

分 类 号：R692.5[医药卫生—泌尿科学] R512.8[医药卫生—外科学]