利伐沙班治疗肺栓塞20例临床疗效观察  

Observation of curative effect by rivaroxaban in the treatment of 20 pulmonary embolism cases

作　　者：张春来[1] 黄炎明[1] 梁丽萍[1] ZHANG Chun-lai HUANG Yan-ming LIANG Li-ping.(Jiangmen City Central Hospital, Jiangmen 529000, Chin)

机构地区：[1]江门市中心医院,529000

出　　处：《中国实用医药》2016年第29期22-24,共3页China Practical Medicine

摘　　要：目的研究肺栓塞(PE)患者应用利伐沙班治疗的临床效果。方法 40例PE患者,根据治疗方法分为观察组与对照组,各20例。观察组采用利伐沙班治疗,对照组采用低分子肝素钙治疗,比较两组临床疗效。结果观察组总有效率为95.0%,明显高于对照组75.0%(P<0.05);治疗后两组呼吸频率(RR)、心率(HR)、动脉血氧分压(Pa O_2)以及二氧化碳分压(Pa CO_2)均较治疗前明显改善(P<0.05),且观察组明显优于对照组(P<0.05);治疗后两组的血D-二聚体(D-D)水平均明显降低(P<0.05),且观察组明显低于对照组(P<0.05);观察组出血反应明显少于对照组(P<0.05)。结论 PE应用利伐沙班治疗效果显著,能够有效改善临床症状且出血反应较少,具有较为广阔的应用前景。但本研究样本数较小,关于其确切效果与安全性还有待进一步大样本研究证实。Objective To research clinical effect by rivaroxaban in the treatment of pulmonary embolism（PE） patients. Methods A total of 40 PE patients were divided by treatment measures into observation group and control group, with 20 cases in each group. The observation group received rivaroxaban for treatment, while the control group received low-molecular-weight heparin calcium. Clinical effects were compared between the two groups. Results The observation group had obviously higher total effective rate as 95.0% than 75.0% of the control group（P〈0.05）. After treatment, both groups had much better respiratory rate（RR）, heart rate（HR）, arterial partial pressure of oxygen（Pa O_2） and arterial partial pressure of carbon dioxide（Pa CO_2） than those before treatment（P〈0.05）, and the observation group had much better indexes than the control group（P〈0.05）. Both groups had remarkably decreased D-dimer（DD） levels after treatment（P〈0.05）, and the observation group had much lower level than the control group（P〈0.05）. The observation group had much fewer hemorrhage reaction than the control group（P〈0.05）. Conclusion Implement of PE provides excellent effect in treating PE. This method can effectively improve clinical symptoms, along with few hemorrhage reaction and bright application prospect. While study on large sample is still necessary, due to small sample in this research, to guarantee practical effect and safety.

关 键 词：肺栓塞 利伐沙班 临床疗效 

分 类 号：R563.5[医药卫生—呼吸系统]