基于单壁金属有机纳米管(SWMONTs)的药物传递系统（英文）  

Drug Delivery System Based on Single-wall Metal-organic Nanotubes(SWMONTs)

作　　者：杨琳燕[1] 龙雨清[1] 路垚[1] 艾霞[1] 马吉飞[1] 金天明[1] Yang Linyan Long Yuqing Lu Yao Ai Xia Ma Jifei Jin Tianming(College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300384, Chin)

机构地区：[1]天津农学院动物科学与动物医学学院,天津300384

出　　处：《南开大学学报（自然科学版）》2016年第5期57-65,共9页Acta Scientiarum Naturalium Universitatis Nankaiensis

基　　金：Supported by National Natural Science Foundation of China(31572492,21371103,31072109,31372482);Tianjin College Outstanding Young Teachers Scheme(J010070501);the Science and Technology Development Fund of Tianjin Agricultural University(2014N03);the Natural Science Foundation of Tianjin(12JCZDJC22100);the Veterinary Biotechnology Scientific Research Innovation Team of Tianjin(TD12-5019);the Veterinary"Leading Talent Culture Project"of Tianjin;Tianjin College Students Innovation and Entrepreneurship Training Program(201610061005)

摘　　要：功能化单壁金属有机纳米管(SWMONTs)可以装载抗癌药物5-氟尿嘧啶(5-FU).材料表征结果表明,药物与SWMONTs的存在比例为每1.0 g载体SWMONTs中含有0.33 g的5-FU.释放曲线表明,在PBS缓冲液(p H=7.4)中24 h释放量为79.6%,而在缓冲液(p H=5.7)中24 h释放量为75%.细胞4T1和RAW264.7被用于细胞毒性实验.2种癌细胞的最高致死率均发生在最高实验浓度的载药体系(5FU@SWMONTs)处理时间最长的样品中.结果表明,5FU@SWMONTs对癌细胞的毒性会因为SWMONTs组分的存在而增强.A self-assembled functionalized metal-organic nanotubes, SWMONTs could be loaded with the anticancer drug 5-Fluorouracil （5-FU）. The characterization of the material indicated the presence of drug associated with SWMONTs （5FU@SWMONTs） in a proportion of 0.33 g 5-FU per 1.0 g of SWMONTs. The drug demonstrated a slow release profile where 79.6% of the drug was released in PBS buffer （pH7.4） in 24 h, while 75% in PBS buffer （pH5.7） in 24 h. The cytotoxic tests were carried out against two cell lines： 4T1 and RAW264.7. The highest lethality of cancer cells occurred at the highest concentration of 5FU@SWMONTs for the longest period of time. The results demonstrate that the cyto- toxicity of 5FU@SWMONTs to cancer cells was improved by the SWMONTs component.

关 键 词：单壁金属有机纳米管 药物传递 细胞增殖 

分 类 号：O614[理学—无机化学]