高血压合并阻塞性睡眠呼吸暂停患者血清胱抑素C的危险因素  

Risk factors of serum cystatin C in hypertensive patients with obstructive sleep apnea

作　　者：赵普庆[1] 刘欣燕[2] 贾维[1] 董斌斌[3] 杨沁彤[4] 吴诚[1] 

机构地区：[1]上海中医药大学附属上海市中西医结合医院呼吸内科,200082 [2]上海中医药大学附属上海市中西医结合医院科研处,200082 [3]复旦大学附属华山医院北院儿科,上海201907 [4]上海中医药大学附属上海市中西医结合医院脉管科,200082

出　　处：《国际心血管病杂志》2016年第6期383-386,共4页International Journal of Cardiovascular Disease

基　　金：上海市卫生和计划生育委员会科研课题(201640098)

摘　　要：目的:探讨高血压合并阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)患者血清胱抑素(CysC)的危险因素。方法:83例高血压患者行血生化和多导睡眠仪检测,根据多导睡眠仪的监测结果,符合OSA诊断的41例患者作为高血压合并OSA组,42例单纯高血压患者作为高血压组。结果:(1)高血压合并OSA组的体质量、体质量指数、颈围、腰围、腰臀比、收缩压、夜间缺氧事件总数、夜间缺氧事件总时间、睡眠呼吸暂停低通气指数(AHI)、空腹血糖、餐后2h血糖、CysC、总胆固醇、三酰甘油和低密度脂蛋白胆固醇均高于高血压组(P均<0.05);(2)Pearson相关或Spearman相关分析显示,血清CysC与体质量、颈围、腰围、腰臀比、夜间缺氧事件总数、夜间缺氧事件总时间和AHI呈正相关(P均<005);(3)多元线性逐步回归分析示仅夜间缺氧事件总数(β=0.484,P<0.05)和AHI(β=0.481,P<0.05)与血清CysC的相关性有统计学意义。结论:夜间缺氧事件总数和AHI是高血压合并OSA患者血清CysC的独立危险因素。Objective：To investigate the risk factor of serum cystatin C in hypertensive patients with obstructive sleep apnea. Methods：According to the results of polysomnograph（PSG）,eightythree hypertensive patients were divided into two groups：hypertension with OSA group（n=41）and hypertension group（n=42）.Blood biochemical examinations were also performed. Results：（1）Weight,body mass index,neck circumference,waist circumference,waist-hip ratio,systolic blood pressure,total number of nocturnal hypoxic events,total time of nocturnal hypoxic events,apneahypopnea index（AHI）,fasting plasma glucose,2-hour plasma glucose,serum cystatin C,total cholesterol,triglyceride and low density lipoprotein cholesterol were significantly higher in hypertension with OSA group than those in hypertension group（all P0.05）.（2）Pearson or Spearman correlation analysis showed that serum cystatin C had significant positive correlation with weight, neckcircumference,waist circumference,waist-hip ratio,total number of nocturnal hypoxic events,total time of nocturnal hypoxic events and AHI.（3）Multiple linear regression analysis showed that only total number of nocturnal hypoxic events（β=0.484,P0.05）and AHI（β=0.481,P0.05）had significant correlation with serum cystatin C. Conclusion：The total number of nocturnal hypoxic events and AHI are independent risk factors for serum cystatin C in hypertensive patients with OSA.

关 键 词：阻塞性睡眠呼吸暂停 高血压 血清胱抑素 夜间缺氧 危险因素 

分 类 号：R544.1[医药卫生—心血管疾病] R766[医药卫生—内科学]