检测呼出气一氧化氮和呼出气冷凝液中白介素-8在慢性阻塞性肺疾病中的临床意义  

The significance of exhaled nitric oixde and interleukin-8 in exhaled breath condensate in the chronic obstructive pulmonary disease

作　　者：刘冬[1] 许西琳[1] 辛雯艳 将雪龙 鲁德玕[1] 

机构地区：[1]石河子大学医学院第一附属医院呼吸一科,新疆石河子832008

出　　处：《包头医学院学报》2016年第11期15-17,共3页Journal of Baotou Medical College

基　　金：科技支疆计划项目(2014AB030)

摘　　要：目的:探讨呼出气一氧化氮(fraction of exhaled nitric oxide,Fe NO)和呼出气冷凝液(exhaled breath condensate,EBC)中白介素-8(interleukin-8,IL-8)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)病情评估中的意义。方法:选择81例COPD急性加重期到COPD稳定期患者作为观察组,78例健康者为对照组,比较两组肺功能,Fe NO水平和EBC中的IL-8的水平。结果:观察组中COPD急性加重期Fe NO、IL-8水平均高于稳定期(P<0.05);COPD稳定期Fe NO、IL-8水平均高于对照组(P<0.05);观察组Fe NO、IL-8水平均高于对照组(P<0.05);相关分析发现Fe NO与IL-8呈正相关。结论:Fe NO、EBC中的IL-8可能在COPD的发生及发展过程中起到重要作用,可能成为反映COPD患者病情严重程度的指标。Objective： To discuss the significance of fraction of exhaled nitric oxide（ Fe NO） and interleukin-8（ IL-8） in exhaled breath condensate in chronic obstructive pulmonary disease（ COPD）. Methods： 81 cases of acute exacerbation of COPD and stable COPD were selected as observation group,and 78 healthy individuals were as control,with pulmonary function,levels of Fe NO and IL-8 in exhaled breath condensate between the two groups compared. Result： Levels of Fe NO and IL-8 in acute exacerbation of COPD of observation group were higher than those in stable COPD of the same group（ P〈0. 05）. Levels of Fe NO and IL-8 of stable COPD were higher than those of control group（ P〈0. 05）,and levels of Fe NO and IL-8 in observation group were higher than those in the control group（ P〈0. 05）. Correlation analysis showed Fe NO and IL-8 correlated positively. Conclusion： Fe NO and IL-8 may play an important role in the development of COPD and may become an index reflecting the severity condition of patients with COPD.

关 键 词：慢性阻塞性肺疾病 呼出气一氧化氮 呼出气冷凝液 IL-8 

分 类 号：R563.9[医药卫生—呼吸系统]