中性粒细胞明胶酶相关脂质运载蛋白检测在新生儿败血症中的应用  

Application of neutrophil gelatinase associated lpocalin in septic newborns

作　　者：杨惠聪[1] 林洁[1] 吴阿阳[1] 杨永青[1] 张富强[1] 王国伟[1] 苏通梅 邹思琦 

机构地区：[1]福建医科大学附属漳州市医院,363000

出　　处：《实用医技杂志》2016年第11期1180-1182,共3页Journal of Practical Medical Techniques

摘　　要：目的探讨新生儿败血症患者对血清、尿液中性粒细胞明胶酶相关脂质运载蛋白(NGAL)水平的影响。方法检测93例新生儿败血症患者(其中败血症55例、严重败血症38例)血清及尿液NGAL水平,在感染治疗期间连续监测3 d。35例无感染新生儿为对照组。同时检测C-反应蛋白(CRP)、血清降钙素原(PCT)等炎症标志物。结果在后续3 d观察中发现败血症特别是严重败血症患者血清和尿液中NGAL水平均升高。血清、尿液中NGAL水平升高的程度与CRP、PCT等炎症标志物有明显的相关性。与新生儿治疗干预评分系统(NTISS)评分也存在明显的相关。结论 NGAL不仅仅是急性肾损伤的指标,也能反映败血症的严重程度。Objective To investigate the application of neutrophil gelatinase associated lipocalin（NGAL）in septic newborns. Methods We determined serum and urine NGAL concentrations in 93 infants（55 with sepsis,38 with severe sepsis）,for three consecutive days during the course of treatment for infection. Thirty-five neonates without infecting served as the control group. Results Septic patients,in particular,severe sepsis patients,had increased serum and urinary NGAL levels in the three subsequent days of observation. A strong correlation was found between the concentration of serum and urinary NGAL and inflammatory markers,such as C-reactive protein（CRP） and pro-calcitonin（PCT）.Serum and urinary NGAL levels were also significantly associated with NTISS values. Conclusion We conclude that increased serum and urinary NGAL values are not solely a marker of AKI,and more accurately reflect the severity of infla mmatory status.

关 键 词：婴儿 新生 出血性败血症 明胶酶类 脂笼蛋白质类 急性肾损伤 

分 类 号：R722.131[医药卫生—儿科]