干扰素-γ和腺苷脱氨酶水平对结核性和癌性胸腔积液的诊断价值  

Diagnostic Value of Interferon-γ and Adenosine Deaminase Levels in Tuberculous and Malignant Pleural Effusion

作　　者：李毅[1] 王建梅[2] 石庆芳[3] 侯宏伟[4] 冯秀丽[2] 

机构地区：[1]河北省胸科医院呼吸科,石家庄050041 [2]河北省胸科医院结核科,石家庄050041 [3]衡水市哈励逊国际和平医院放疗科,河北衡水053000 [4]河北省胸科医院检验科,石家庄050041

出　　处：《解放军医药杂志》2016年第11期66-68,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：河北省医学科学研究重点课题计划(ZD20140501)

摘　　要：目的研究干扰素-r(IFN-r)和腺苷脱氨酶(ADA)水平对结核性和癌性胸腔积液的诊断价值。方法选取2014年5月—2015年5月河北省胸科医院收治的胸腔积液患者118例,其中结核性胸腔积液59例(结核组),癌性胸腔积液28例(癌性组),炎性胸腔积液22例(炎性组),其他原因引起胸腔积液9例(其他组),检测4组胸腔积液中的INF-r和ADA水平,并进行比较。结果结核组INF-r、ADA水平均高于癌性组、炎性组及其他组(P<0.05);癌性组INF-r、ADA水平均高于炎性组及其他组(P<0.05)。INF-r+ADA联合诊断结核性胸腔积液较单独诊断的特异度高,差异具有统计学意义(P<0.05)。结论 INF-r和ADA水平对结核性和癌性胸腔积液有诊断价值,且能鉴别结核性和癌性胸腔积液,两者联合更有助于结核性胸腔积液的诊断。Objective To study value of interferon-γ（INF-r） and adenosine deaminase（ADA） levels in diagnosis of tuberculous and malignant pleural effusion.Methods A total of 118 patients with pleural effusion admitted during May 2014 and May 2015 were divided into tuberculous pleural effusion（TB group,n = 59）,malignant pleural effusion（cancer group,n = 28）,inflammatory pleural effusion（inflammatory group,n = 22） and other causes of pleural effusion groups（other group,n = 9）.INF-r and ADA levels were detected and compared in four groups.Results INF-r and ADA levels in TB group were higher than those in cancer,inflammatory and other groups（P〈0.05）.INF-r and ADA levels in cancer group were higher than those in inflammatory and other groups（P〈0.05）.Specificity degree of INF-r combined with ADA was higher than that of separate one in diagnosis of tuberculous pleural effusion,and the difference was statistically significant（P〈0.05）.Conclusion INF-r and ADA levels have value in diagnosis of tuberculous and malignant pleural effusion,and it can identify tuberculous and malignant pleural effusion,and INF-r combined with ADA is more helpful in diagnosis of tuberculous pleural effusion.

关 键 词：干扰素-r 腺苷脱氨酶 胸腔积液 结核性 胸腔积液 恶性 

分 类 号：R561.3[医药卫生—呼吸系统] R341[医药卫生—内科学]