东莨菪碱和地塞米松联合抢救急性中毒性肺水肿的可行性及对症状消失时间的影响  

The feasibility of Scopolamine combined with Dexamethasone acute toxic pulmonary edema and influence of symptoms disappear time

作　　者：钟建华[1] 

机构地区：[1]江西省会昌县人民医院急诊科,江西会昌342600

出　　处：《中国当代医药》2016年第32期38-40,共3页China Modern Medicine

摘　　要：目的探讨东莨菪碱和地塞米松联合抢救急性中毒性肺水肿（ATPE）的可行性及对症状消失时间的影响。方法 选取2012年1月～2016年6月在我院接受抢救治疗的ATPE患者72例,根据治疗方式随机分为对照组和观察组,每组36例,其中对照组采用地塞米松治疗,5～10 mg/次,24 h用量15～30 mg。观察组采用东莨菪碱（1～3 mg/次,15～30 min/次,静脉滴注）＋地塞米松（5～10 mg/次,24 h用量15～30 mg）治疗。比较两组的治疗效果、症状消失时间及并发症情况。结果 观察组药物起效时间及肺水肿消失时间均显著短于对照组（P〈0.05）;观察组治愈率显著高于对照组（91.67%vs 69.44%,P〈0.05）,而并发症发生率明显低于对照组（5.56%vs 22.22%,P〈0.05）;两组死亡率差异无统计学意义（P〉0.05）。结论 东莨菪碱联合地塞米松可有效提高ATPE的治愈率,具有起效迅速、症状缓解快、并发症少等特点,临床应用价值较高。Objective To investigate the feasibility of Scopolamine combined with Dexamethasone acute toxic pulmonary edema and influence of symptoms disappear time.Methods 72 patients with ATPE given emergency treatment in our hospital from January 2012 to June 2016 were selected and they were randomly divided into the control group and the observation group,there were 36 cases in each group.The control group was treated with 5～10 mg Dexamethasone every time,the total dose in 24 h was 15～30 mg and the observation group was treated with Scopolamine（intravenous infusion of 1 ～3 mg, 15 ～30 min） combined with Dexamethasone.The treatment effect,symptom disappearance time and complication of the two groups were compared.Results The drug onset time and pulmonary edema disappearance time of the observation group were significantly shorter than those of the control group（P〈0.05）.The cure rate of the observation group was significantly higher than that of the control group（91.67% vs 69.44%,P〈0.05）,and the complication rate was significantly lower than the control group（5.56% vs 22.22%,P〈0.05）.There was no significant difference in mortality between two groups（P〉0.05）.Conclusion Scopolamine combined with Dexamethasone can effectively improve the cure rate of ATPE,with the characteristics of rapid onset,fast symptoms,less complications and so on,the higher the value of clinical application.

关 键 词：急性中毒性肺水肿 东莨菪碱 地塞米松 急救 

分 类 号：R541.63[医药卫生—心血管疾病]