脓毒症致急性呼吸窘迫综合征的研究进展  

Developments on acute respiratory distress syndrome induced by sepsis

作　　者：瞿海龙[1] 周英莲[1] 刘鹏[1] 张新欣[1] 彭广军[1] 

机构地区：[1]河北大学附属医院急诊科,河北保定071000

出　　处：《医学研究与教育》2016年第5期30-34,共5页Medical Research and Education

摘　　要：严重脓毒症或脓毒症休克是指由病原微生物感染引起的机体过度炎性反应。急性呼吸窘迫综合征是严重脓毒症的一个致命性并发症,此类患者具有较高的病死率。在过去的十几年里,对于急性呼吸窘迫综合征治疗取得了显著进步,包括保护性的肺通气策略、俯卧位通气、神经肌肉阻滞剂的应用、体外膜式氧合,然而病死率仍高居不下。对脓毒症的早期治疗和急性呼吸窘迫综合征早期发现可减少疾病的进展。此外仍需对脓毒症导致的急性呼吸窘迫综合征的发病机制和新型治疗手段进行研究,以便发现更有希望的治疗方法。Severe sepsis or septic shock is characterized by an excessive inflammatory response to infectious pathogens.Acute respiratory distress syndrome （ARDS） is a devastating complication of severe sepsis,in which patients have high mortality.Advances in treatment modalities including lung protective ventilation,prone positioning,use of neuromuscular blockade,and extracorporeal membrane oxygenation,have improved the outcome over recent decades,nevertheless,the mortality rate still remains high.Timely treatment of underlying sepsis and early identification of patients at risk of ARDS can help to decrease its development.In addition,further studies are needed regarding pathogenesis and novel therapies in order to show promising future treatments of sepsisinduced ARDS.

关 键 词：脓毒症 休克 急性呼吸窘迫综合征 

分 类 号：R563.8[医药卫生—呼吸系统]