临床药师干预用药依从性在心肌梗死二级预防中的作用  

Function of clinical pharmacy interventions on secondary prevention of myocardial infarction

作　　者：甘井山[1] 徐亚洁[1] 运乃茹[1] 刘秀书[1] 李鸥[1] 

机构地区：[1]天津中医药大学第二附属医院药学部,天津300150

出　　处：《天津中医药》2016年第11期654-657,共4页Tianjin Journal of Traditional Chinese Medicine

基　　金：天津市中医药管理局中医中西医结合科研专项课题(13092)

摘　　要：[目的]探讨药学服务对心肌梗死二级预防患者用药依从性的影响。[方法]选择心肌梗死患者200例,随机分为干预组和对照组,每组100例。干预组由临床药师提供药学服务,对照组按常规治疗服药不予干预。分别于药师干预1、3、6、9、12个月后记录两组患者的用药依从性及漏服率。记录药师干预1 a后两组患者的心肌梗死再梗率、住院率和病死率。[结果]与对照组比较,干预组患者的用药依从性于药师干预3个月后显著提高(P<0.05),漏服率则于药师干预3个月后显著降低(P<0.05)。干预组患者的心肌梗死再梗率及住院率,与对照组患者比较明显降低(P<0.05)。干预组患者的病死率,与对照组患者比较差异不具统计学意义(P>0.05)。[结论]药学服务能提高心肌梗死二级预防患者用药依从性,降低其漏服率、心肌梗死再梗率及住院率。[Objective] To explore the influence of clinical pharmacy interventions on secondary prevention of myocardial infarction. [Methods] Two hundred patients diagnosed as myocardial infarction were enrolled in this study, and these patients were randomly divided into intervention group and control group. All of the patients received conventional treatment, while the patients in the intervention group received clinical pharmacy intervention provided by pharmacists. The medication adherence and the adherence rate was recorded after intervened 1, 3, 6, 9, 12 months and the recurrence rate of myocardial infarction, hospitalization rate, and mortality were recorded after intervened 1 year. [Results] Compared with the control group, the medication adherence of the intervention group increased significantly since 3 months after intervened （P〈0.05）, while the adherence rate of the intervention group was decreased significantly since 3 months after intervened （P〈0.05）. The recurrence rate of myocardial infarction and the hospitalization rate of the intervention group decreased significantly （P〈0.05）, but mortality of the intervention group has no statistically significance compared with the control group （P〉0.05）. [Conclusion] Clinical pharmacy interventions could improve the medication adherence of the secondary prevention of the patient with myocardial infarction, decrease the adherence rate of the patients, and reduce the recurrence rate the hospitalization rate of myocardial infarction.

关 键 词：心肌梗死 二级预防 药学干预 用药依从性 

分 类 号：R542.2[医药卫生—心血管疾病]