均相自发泡法制备抗菌多孔复合骨修复支架  

Preparation of antibacterial composite porous scaffolds by homogeneous self-foaming method

作　　者：李根[1] 李丽梅[1] 蒋佳兴 李炯炯 左奕[1] 李玉宝[1] 邹琴[1] 张利[1] 李吉东[1] 

机构地区：[1]四川大学分析测试中心,成都610064

出　　处：《功能材料》2016年第6期176-180,共5页Journal of Functional Materials

基　　金：国家高技术研究发展计划(863计划)重点资助项目(2013AA032203);国家自然科学基金资助项目(31370971);四川大学优秀青年学者基金资助项目(2014SCU04A20)

摘　　要：与植入骨修复材料相关的感染仍是临床面临的难题,能控释或缓释抗菌剂的骨修复材料在易感染骨缺损修复领域越来越受到青睐。在具有良好生物相容性和成骨作用的纳米羟基磷灰石/聚氨酯(nHA/PU)复合材料中添加磷酸银作为抗菌剂,复合磷酸氢钙结晶水合物(DCPD)作为发泡剂水的来源,通过释放DCPD中结晶水与PU中异氰酸根反应产生CO_2气体实现了复合材料均相发泡成型。实验结果显示,85℃条件下自发泡制备的载磷酸银羟基磷灰石/磷酸氢钙/聚氨酯(Ag_3PO_4-nHA/DCPD/PU)复合支架的孔隙率高达80%,抗压强度可达2.83 MPa;制备的抗菌支架能有效抑制细菌在材料表面黏附,与细菌接触24h后抑菌率可达95.45%。该方法简便易行,制备的孔隙分布均匀、贯通性好、孔隙率高和力学性能佳的抗菌复合支架在骨修复领域有较大的应用潜力。Infection associated with implanted bone repair materials is still a challenging issue in clinic.The bone repair materials with local drug-delivery capacity have drew much attention in susceptible bone defect repair re-cently.In the present study,Ag3PO4 was selected as an antibacterial agent and incorporated into the nano-hydroxyapatite/polyurethane （nHA/PU）composite,which have been proved to be a biocompatible materials with good osteogenesis.Calcium hydrogen phosphate dihydrate （DCPD）was add into the nHA/PU composite and served as foaming agent.Under certain condition,the crystalline water can release from DCPD and react with isocyanate（—NCO）to generate CO2 ,resulting in the homogeneous self-foaming of the composite.The re-sults revealed that the porosity and compressive strength of fabricated Ag3PO4 loaded nano-hydroxyapatite/Cal-cium hydrogen phosphate dihydrate/polyurethane （Ag3PO4-nHA/DCPD/PU）composite scaffolds can reach 80.7% and 95.45%,respectively.The fabricated Ag3PO4-nHA/DCPD/PU scaffolds also can prevent bacteria adhesion on the material surface effectively and bacteriostatic rate can reach 95.45% after incubation the bacteria with the materials for 24 h.The resultant Ag3PO4-nHA/DCPD/PU composite scaffolds with high porosity,u-niform porous structure and interconnectivity as well as strong antibacterial properties fabricated by such a facile method have a great potential to be applied in the fields of bone repair.

关 键 词：抗菌 聚氨酯 纳米羟基磷灰石 磷酸银 自发泡 

分 类 号：TB33[一般工业技术—材料科学与工程]