靶向MAPK信号通路调控脂肪细胞分化的microRNAs  

Regulation of Adipocyte Differentiation via microRNAs Targeting MAPK Signaling Pathway

作　　者：张秀秀[1] 郭云涛[1] 黄万龙[1] 李嫒[1] 苗向阳[1] ZHANG Xiu-xiu GUO Yun-tao HUANG Wan-long LI Yuan MIAO Xiang-yang(Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China)

机构地区：[1]中国农业科学院北京畜牧兽医研究所,北京100193

出　　处：《畜牧兽医学报》2016年第11期2159-2166,共8页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：转基因生物新品种培育科技重大专项(2009ZX08008-004B;2008ZX08008-003);国家"863"计划项目(2008AA10Z140);国家自然科学基金项目(30571339);中国农业科学院农业科技创新项目(ASTIP-IAS05);中国农业科学院创新基金项目(2004-院-1);国家重点基础研究发展计划("973"计划)(2015CB943100);中央级公益性科研院所基本科研业务费专项资金项目(2013ywf-yb-5;2013ywf-zd-2)

摘　　要：脂肪细胞分化是一个多能间充质干细胞(MSCs)逐渐向成熟脂肪细胞分化的复杂过程,该过程受很多转录因子、激素以及信号通路相关分子的严格调控。体内外的试验表明,microRNAs(miRNAs)也参与了脂肪细胞分化的调节,且可以靶向转录因子和信号通路中的关键分子发挥作用。丝裂原活化蛋白激酶(MAPK)信号通路是真核细胞将胞外信号转导至胞内引起细胞反应的一类重要信号系统,研究证明,miRNAs可以靶向MAPK信号通路中的某些基因,影响该通路的信号转导,参与脂肪细胞分化的调控。因此本文总结了近几年有关miRNA改变MAPK信号转导,实现调控脂肪细胞分化功能的研究,以期为深入了解脂肪细胞分化的机制,为治疗脂肪型疾病提供新的思路。Adipocyte differentiation is a complicated process in which pluripotent mesenchymal stem cells（MSCs）differentiate into mature adipocytes.The process of adipocyte differentiation is strictly regulated by a number of transcription factors,hormones and signaling pathway molecules.In vivo and in vitro research has revealed that microRNAs（miRNAs）are also involved in adipocyte differentiation and play a role by targeting transcription factors and key signaling molecules.MAPK signaling pathway is one of important signaling systems which transduce the extracellular signal to intracellular space and cause cell response.The studies showed that,miRNAs can target certain genes in MAPK and affect its signal transduction,thus regulating adipocyte differentiation.Therefore,a summary of researches how miRNAs change the signal transduction of MAPK pathway and regulate adipocyte differentiation was performed in order to further understand the adipocyte differentiation mechanism and offer new ideas for curing the fat-associated diseases.

关 键 词：microRNA MAPK信号通路 靶基因 脂肪细胞分化 

分 类 号：S813.2[农业科学—畜牧学]