糖皮质激素受体基因、工作紧张水平的交互作用与创伤后应激障碍易感性的关系  

Association Between Interaction of Glucocorticoid Receptor Genes and Work Stress Levels and Susceptibility of Post-Traumatic Stress Disorder

作　　者：李树林[1,2] 王泽[1] 王茜[1] 

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830000 [2]乌鲁木齐市急救中心,新疆乌鲁木齐830000

出　　处：《环境与职业医学》2016年第11期1076-1079,共4页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金(编号:30800906)

摘　　要：[目的]分析创伤后应激障碍（PTSD）的主要危险因素,探讨糖皮质激素受体（GR）基因rs17209237、rs41423247位点与紧张水平的交互作用,为筛选PTSD敏感人群提供依据。[方法]采用病例对照研究方法,以新疆某三甲医院确诊治疗的PTSD患者（60例）作为病例组,以同期经三甲医院确诊遭受过创伤性事件,但没有发展为PTSD的120例为对照组,进行量表调查（工作紧张测量问卷）和血样采集（经知情同意,早晨空腹采集静脉血样5 m L）,用于分析GR基因与紧张水平的交互作用。[结果]工作紧张中,子项工作紧张强度病例组高于对照组（P〈0.05）,OR值为6.122;工作压力在病例组和对照组差异有统计学意义,病例组的工作压力高于对照组（P〈0.05）,OR值为10.543。GR基因rs41423247位点C/G基因型的频率分布病例组高于对照组（P〈0.05）,C等位基因携带者GC可能是PTSD的危险因素（OR=2.14,95%CI：1.10~4.16）。GR基因rs41423247位点突变型与工作压力正相乘交互作用（P〈0.05）,OR值为3.256。[结论]工作紧张强度和工作压力大者PTSD的患病风险高。GR基因rs41423247位点C等位基因携带者GC PTSD发病风险高。GR基因是PTSD的遗传易感基因,GR基因rs41423247位点与工作压力共同作用可能增加PTSD的患病风险。[ Objective ] To examine the major risk factors of post-traumatic stress disorder （PTSD）, assess the interaction of glucocorticoid receptor （GR） gene rs17209237 and rs41423247 and work stress levels, and provide evidence for screening sensitive populations of PTSD. [ Methods ] The study adopted a case-control design. Patients from tertiary grade A hospitals in Xinjiang diagnosed with PTSD （n=60） were enrolled as the case group, and those who suffered a traumatic event diagnosed in the same period but did not develop to PTSD （n=120） were enrolled as the control group. They were investigated with Job Stress Survey （JSS） and gave informed consent to collect morning fasting venous blood samples （5 mL）. GR gene-stress interaction was assessed. [ Results ] Job stress intensity in the case group was higher than that in the control group （P〈0.05） （OR=6.122）, so was the job pressure （P〈 0.05） （0R=10.543）. The frequency of GR gene rs41423247 C/G genotype in the case group was higher than that in the control group （P〈0.05）, and C allele carrier （GC） was a risk factor for PTSD （OR=2.14, 95%CI： 1.10-4.16）. There was a positive multiplication interaction between GR gene rs41423247 mutant type and job pressure （P〈 0.05） （0R=3.256）. [ Conclusion ] Job stress intensity and job pressure increase the possibility of suffering from PTSD. GR gene rs41423247 locus C allele （GC） increases the possibility of suffering from PTSD. GR gene is a genetic risk factor for PTSD, and the joint action of GR gene rs41423247 and job pressure increases the risk of PTSD.

关 键 词：糖皮质激素受体基因 紧张水平 创伤后应激障碍 病例对照研究 

分 类 号：R135.99[医药卫生—劳动卫生]