肥胖及其相关疾病对纳米颗粒物健康损伤效应影响的研究进展  

Potential Effects of Obesity and Associated Diseases on Nanoparticles-Induced Toxicity: An Overview

作　　者：李芳[1] 万斯傲 闫庆韬 王晓彤[1] 董颖[1] 王苏华[1] 沈海俊[1] 陆荣柱[1] 

机构地区：[1]江苏大学医学院预防医学与卫生检验系,江苏镇江212013

出　　处：《环境与职业医学》2016年第11期1110-1114,共5页Journal of Environmental and Occupational Medicine

基　　金：国家自然科学基金(编号:81302459;308721399);中国博士后科学基金面上资助(编号:2013M540424);中国博士后科学基金特别资助(编号:2015T80513);江苏大学高级专业人才科研启动基金项目(编号:13JDG024);江苏省博士后科学基金(编号:1302151C)

摘　　要：肥胖及其相关疾病改变了毒物代谢动力学特征,诱发机体炎症反应和氧化应激,因而可能改变纳米颗粒物对该人群的健康损伤效应。已有研究发现,糖尿病可加重纳米颗粒物的自主神经、感觉和认知功能的损伤;加快纳米颗粒物引起的血小板聚集,加速血栓、动脉粥样硬化和斑块的形成,增加心血管疾病发病率或者加剧其进程。同时,超重或肥胖及其相关的血脂异常、非酒精性脂肪肝,也加重了纳米颗粒物激发的炎症调节反应以及相应的肺部、肝组织的损伤。因而,在职业和生活环境中接触纳米颗粒物时,应针对纳米颗粒物的理化特性和肥胖相关疾病患者的生理特点,为这一特殊易感人群提供相应的防护措施。Obesity and associated diseases change toxicokinetic characteristics of chemicals, induce inflammation and oxidative stress, and may aggravate nanoparticles-induced toxicity. Diabetes can deteriorate nanoparticles-induced adverse health effects on the functions of autonomic nerve, sense, and cognition, as well as accelerate the platelet aggregation induced by nanoparticles exposure, thrombosis, atherosclerosis, and plaque development in patients with diabetes mellitus, resulting in the onset or advancement of cardiovascular disease. In addition, hyperlipidemia and nonalcoholic fatty liver related with overweight or obesity exacerbate inflammation and tissue injury induced by nanoparticles. Therefore, based on the physicochemical characteristics of nanoparticles and the physiological characteristics of patients with obesity and associated diseases, a specific policy should be developed to protect the vulnerable population from nanoparticles-induced toxic effects in occupational and living environments.

关 键 词：肥胖 糖尿病 高血压 血脂异常 非酒精性脂肪肝 纳米颗粒 超细颗粒物 健康损伤 

分 类 号：R114[医药卫生—卫生毒理学]