心率变异性与急性冠脉综合征患者冠状动脉病变程度的相关性研究  

Correlation Between Heart Rate Variability and Severity of Coronary Artery Lesions of Patients With Acute Coronary Syndrome

作　　者：陆艳[1] 曹燕[1] LU Yan CAO Yan(Department of Cardiology, the First Hospital of Xi ＇ an, Xi＇an 710002, China)

机构地区：[1]陕西省西安市第一医院心内科,710002

出　　处：《实用心脑肺血管病杂志》2016年第6期16-18,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：陕西省科学技术研究发展计划项目(2014k11)

摘　　要：目的分析心率变异性与急性冠脉综合征(ACS)患者冠状动脉病变程度的相关性。方法选取2013年11月—2015年11月西安市第一医院收治的ACS患者250例作为ACS组,根据冠状动脉病变程度分为轻度组69例、中度组123例、重度组58例;另选取同期体检健康者65例作为对照组。采用冠状动脉造影检查冠状动脉病变程度,24 h动态心电图监测心率变异性指标,并分析心率变异性指标与ACS患者冠状动脉病变程度间的相关性。结果 ACS组患者冠状动脉病变支数多于对照组,Gensini评分高于对照组(P<0.05)。ACS组患者窦性N-N间期标准差(SDNN)、5 min N-N间期平均值标准差(SDANN)、极低频功率(VLF)、低频功率(LF)、高频功率(HF)低于对照组(P<0.05)。重度组患者SDNN、SDANN、VLF、LF、HF低于轻度组、中度组,中度组患者SDNN、SDANN、VLF、LF、HF低于轻度组(P<0.05);Pearson相关性分析结果显示,Gensini评分与SDNN、SDANN、VLF、LF、HF呈负相关(r值分别为-0.846、-0.634、-0.718、-0.536、-0.604,P<0.05)。结论心率变异性与ACS患者冠状动脉病变程度有关,且心率变异性对冠状动脉病变具有一定的预测价值。Objective To analyze the correlation between heart rate variability and severity of coronary artery lesions of patients with acute coronary syndrome. Methods A total of 250 patients with acute coronary syndrome were selected as ACS group in the First Hospital of Xi＇an from November 2013 to November 2015,and they were divided into A group（ with mild coronary artery stenosis,n = 69）,B group（ with moderate coronary artery stenosis,n = 123） and C group（ with severe coronary artery stenosis,n = 58）according to the severity of coronary artery stenosis;a total of 65 healthy cases admitted to this hospital for physical examination were selected as D group at the same time. Coronary angiography was used to examine the severity of coronary artery lesions,24 - hour dynamic electrocardiogram was used to monitor the index of heart rate variability, and the correlation between index of heart rate variability and severity of coronary artery lesions of patients with acute coronary syndrome was analyzed. Results The number of coronary arteries with lesions of ACS group was statistically significantly more than that of D group,and Gensini score of ACS group was statistically significantly higher than that of D group（ P ﹤ 0. 05）. SDNN,SDANN,VLF,LF and HF of ACS group were statistically significantly lower than those of D group（ P ﹤ 0. 05）. SDNN,SDANN,VLF,LF and HF of C group were statistically significantly lower than those of A group and B group,SDNN, SDANN,VLF,LF and HF of B group were statistically significantly lower than those of A group（ P ﹤ 0. 05 ）;Pearson correlation analysis showed that,Gensini score was negatively correlated with SDNN,SDANN,VLF,LF and HF,respectively （r = - 0. 846, - 0. 634, - 0. 718, - 0. 536, - 0. 604,P ﹤ 0. 05）. Conclusion Heart rate variability is correlated with the severity of coronary artery lesions of ACS patients,heart rate variability has certain predictive value on coronary artery lesions.

关 键 词：急性冠脉综合征 冠状血管造影术 心电描记术 

分 类 号：R542.2[医药卫生—心血管疾病]