幽门螺杆菌感染与老年缺血性心脏病的关系研究  

Relationship Between H. pylori Infection and Ischemic Heart Disease in Elderly Patients

作　　者：张淑珍 张建君 梅大平 刘娜 蒋娟 张雪亚 ZHANG Shu-zhen ZHANG Jian-jun MEI Da-ping LIU Na JIANG Juan ZHANG Xue-ya(Department oflnternal Medicine, the Second Hospital of Weinan, Weinan 714000, China)

机构地区：[1]陕西省渭南市第二医院内科,714000

出　　处：《实用心脑肺血管病杂志》2016年第6期27-29,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的探究幽门螺杆菌感染与老年缺血性心脏病的关系。方法选取渭南市第二医院2012年5月—2014年5月收治的老年缺血性心脏病患者110例,其中伴幽门螺杆菌感染者47例(感染组),不伴幽门螺杆菌感染者63例(对照组)。回顾性分析两组患者的临床资料,记录其实验室检查指标〔包括空腹血糖(FBG)、血小板计数(PLT)、纤维蛋白原(FIB)、血脂指标及C反应蛋白(CRP)〕及心功能分级,并分析幽门螺杆菌感染与心功能分级的相关性。结果感染组患者FBG及FIB、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、CRP水平高于对照组,PLT和高密度脂蛋白胆固醇(HDL-C)水平低于对照组(P<0.05);两组患者总胆固醇(TC)水平比较,差异无统计学意义(P>0.05)。感染组患者心功能分级劣于对照组(u=4.081,P=0.000),且幽门螺旋菌感染与心功能分级呈中等相关(列联系数=0.557)。结论幽门螺杆菌可能通过影响血脂代谢及CRP水平而参与老年缺血性心脏病的发生和发展,且幽门螺杆菌感染与老年缺血性心脏病患者心功能损伤程度有关。Objective To explore the relationship between H. pylori infection and ischemic heart disease in elderly patients. Methods From May 2012 to May 2014,a total of 110 elderly patients with ischemic heart disease were selected in the Department of Internal Medicine,the Second Hospital of Weinan,thereinto 47 cases with H. pylori infection were selected as A group,other 63 cases without H. pylori infection were selected as B group. Clinical data was retrospectively analyzed,including laboratory examination results（including FBG,FIB,blood liquids index and CRP）and NYHA cardiac functional grading,the relationship between H. pylori infection and NYHA cardiac functional grading was analyzed. Results FBG,FIB,TG,LDL-C and CRP of A group were statisticallysignificantly higher than those of B group,while PLT and HDL-C of A group were statistically significantly lower than those of B group（P ﹤ 0. 05）;no statistically significant differences of TC was found between the two groups（P ﹥ 0. 05）. The NYHA cardiac functional grading of A group was statistically significantly worse than that of B group（ u = 4. 081,P = 0. 000 ）,and H. pylori infection was mediumly correlated with NYHA cardiac functional grading （coefficient of contingency was 0. 557）. Conclusion H. pylori infection plays an import role in the initiation and development of schemic heart disease in elderly patients,possibly by affecting the blood lipid metabolism and CRP,and H. pylori infection is certainly correlated with the heart function damage degree.

关 键 词：心肌缺血 老年人 幽门螺杆菌 感染 

分 类 号：R542.2[医药卫生—心血管疾病]