《回回药方》阿夫忒蒙丸对失眠患者TCD的影响  

The effect of Afuteimengwan on TCD in patients with intractable insomnia

作　　者：王晓丽[1] 余静[1] 蒋敏之 刘丽[1] 贾孟辉[1] 

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001

出　　处：《宁夏医学杂志》2016年第11期1025-1027,共3页Ningxia Medical Journal

基　　金：宁夏银川市科技计划项目(2014056)

摘　　要：目的观察阿夫忒蒙丸对顽固性失眠患者经颅多普勒超声(TCD)的影响。方法将符合纳入标准的顽固性失眠患者80例,随机分为阿夫忒蒙丸高剂量组(AH组)、阿夫忒蒙丸中剂量组(AM组)、阿夫忒蒙丸低剂量组(AL组)和对照组(CG组)4组,每组20例。治疗组口服阿夫忒蒙丸(高、中、低剂量组,分别采用9 g/次、6 g/次、3 g/次),对照组给予艾司唑仑片(1 mg/次),14 d为1个疗程。2个疗程后观察分析椎动脉、基底动脉的血流速度及临床疗效。结果临床疗效比较:对照组显效率为50%,有效率为75%,与对照组相比,阿夫忒蒙丸各剂量组显效率与有效率差异有统计学意义(P<0.05),其中以阿夫忒蒙丸高剂量组的差异最为明显(P<0.05)。椎-基底动脉的血流速度比较:组间比较时,各组患者治疗前椎-基底动脉的收缩峰血流速度(Vs)、舒张末血流速度(Vd)、平均血流速度(Vm)相比,差异无统计学意义(P>0.05);治疗后与CG组比较,AL、AM、AH组Vs、Vd均有提高(P<0.05),尤以AH组增速为甚(P<0.05)。组内比较,各组治疗前后Vs、Vd差异有统计学意义(P<0.05),其中以AH组差异最为明显(P<0.05)。结论阿夫忒蒙丸能够明显升高Vs,其治疗顽固性失眠的效果显著。Objective To observe the effect of Muteimengwan on the patients with intractable insomnia in TCD. Methods 80 cases with intractable insomnia were randomly divided into four groups： high ,medium and low dose group of Afuteimengwan and the control group,and 20 cases in each group. The patients in the treatment group were treated with oral Afuteimengwan ,and the dosage was 9 g,6 g, 3 g,three times a day. The patients in the control group were treated with oral estazolam tablets,ling every day. 14 days for one course of treatment,after two courses with respective treatment,the blood flow velocity of vertebral artery, basilar artery and the clinical effect were observed in the patients. Results Compared the clinical curative effect：the effective rate of the control group was 50% ,the effective rate was 75% ,Compared with the control group,The efficiency and effectiveness of each Muteimengwan dose group were statistically significant （P 〈 0.05 ）. The high dose group was significantly （P 〈 0.05 ） ;Compared the blood flow velocity of vertebral basilar artery： before treat- ment ,there were no statistical significance in the peak flow velocity （Vs） ,diastolic blood flow velocity （Vd） and average blood flow veloci- ty （Vm） of the vertebral basilar artery between groups （ P 〉 0.05）. After treatment, the systolic peak flow velocity （Vs） and diastolic blood flow velocity （Vd） of the vertebral basilar artery of in the Muteimengwan group were increased （ P 〈 0.05 ）. Especially it was increased sig- nificantly in high dose group （ P 〈 0.05 ）. Before and after treatment, the systolic blood flow velocity （Vs） and diastolic blood flow velocity （Vd） of the vertebral basilar artery were statistically significant （P 〈 0.05 ）. Conclusion Afuteimengwan can significantly reduce the ver- tebral basilar artery blood flow velocity ,it has significant effect on the patients of Intractable insomnia.

关 键 词：阿夫忒蒙丸 顽固性失眠 经颅多普勒 血流速度 

分 类 号：R29[医药卫生—民族医学]