肠道菌群特征与胰岛素抵抗的相关性研究  

Study on correlation between intestinal flora characteristic and insulin resistance

作　　者：熊青[1] 杨学军[1] 任汐[1] 林慧[1] 

机构地区：[1]海南省海口市人民医院内分泌科,570208

出　　处：《重庆医学》2016年第33期4658-4660,共3页Chongqing medicine

摘　　要：目的探讨糖尿病前期人群肠道菌群的改变与胰岛素抵抗的相关关系及肠道菌群在糖尿病前期人群糖尿病发生、发展中的作用。方法选取该院糖尿病前期人群250例,分为A组(前期干预组)和B组(前期无处理组),糖尿病人群50例为C组(阳性对照组),采用队列研究随访干预2年,分别测定不同时期的肠道菌群情况及血液生化指标,计算胰岛素抵抗指数。结果干预前,A、B组总菌数显著高于C组;C组肠球菌属显著高于A、B组;A、B组变形杆菌、乳酸杆菌含量高于C组,差异无统计学意义;C组双歧杆菌属高于A、B组。干预后,A组细菌总量显著高于B、C组,B、C两组无差异;C组肠球菌属显著高于A、B组,干预后A组肠球菌属降低,B组升高,差异有统计学意义;A、B组变形杆菌、乳酸杆菌含量高于C组,差异不明显;C组双歧杆菌属高于A、B组,且干预后B组数量升高,差异有统计学意义。处理前,A、B组胰岛素抵抗差异无统计学意义,C组胰岛素抵抗高于A、B组,干预后,A组胰岛素抵抗降低,差异有统计学意义。总菌数、肠球菌属、双歧杆菌属与胰岛素抵抗之间呈正相关,拟杆菌属、变形杆菌、乳酸杆菌与胰岛素抵抗的相关不显著。结论肠道菌群与胰岛素抵抗存在相关关系,可作为糖尿病前期发展的标志,通过益生菌调节,结合量化有氧肌肉运动,可实现对胰岛素敏感性的调整,改善糖尿病前期人群糖尿病的发展。Objective To explore the correlation between the change of intestinal flora and insulin resistance in pre-diabetes population,and the role of intestinal flora in the occurrence and development in the pre-diabetes population.Methods two hundreds and fifty cases of pre-diabetes in our hospital were selected and divided into the group A（pre-diabetes intervention group）and B（prediabetes non-treatment group）.Fifty cases of diabetes（positive control group）served as the group C.The cohort study was adopted.The follow-up intervention lasted for two years.The intestinal flora and blood biochemical indicators were detected in different groups and at different time periods.The insulin resistance index was calculated.Results The total bacterial count before intervention in the group A and B was significantly higher than that in the group C;Enterococcus genus in the group C was significantly higher than that in the group A and B;the proteus and lactobacillus content in the group A and B was higher than that in the group C,but the difference was not significant;Bifidobacterium genus in the group C was higher than that in the group A and B.After intervention,the total bacterial amount in the group A was significantly higher than the group B and C,but there was no statistical difference between the group B and C;enterococcus genus in the group C was significantly higher than that in the group A and B,enterococcus genus after intervention in the group A was reduced and which in the group B was increased,the difference had statistical significance;the proteus and lactobacillus content in the group A and B was higher than that in the group C,but the difference was not significant;bifidobacterium genus in the group C was higher than that in the group A and B,moreover which after intervention in the group B was increased,the difference was statistically significant.The insulin resistance before processing had no statistical difference between the groups A and B,which in the group C was higher than the group A and B,the in

关 键 词：糖尿病前期 胰岛素抵抗 肠道菌群 发生发展 

分 类 号：R587.1[医药卫生—内分泌]