苯并噁唑与苯并噻唑的合成方法  

Methods for Synthesis of Benzoxazole and Benzothiazole

作　　者：周晓玉[1] 陈霞[1] 杨发旺[1] 刘义龙[1] 令狐克美 

机构地区：[1]六盘水师范学院化学与化学工程系,贵州六盘水553004

出　　处：《广州化工》2016年第22期39-41,共3页GuangZhou Chemical Industry

基　　金：黔科合LH字[2015]7614号;六盘水师范学院高层次人才科研启动基金(LPSSYKYJJ201501)

摘　　要：苯并噁唑和苯并噻唑等芳香杂环化合物是一类重要的有机合成中间体,是许多医药、农药、天然产物和功能分子等的骨架结构。因此,该类化合物的合成备受广大研究者的关注。本文着重综述了近年来此类化合物的合成发展情况,按照分子间缩合和分子内缩合反应进行分类归纳总结。文章还结合目前有机合成的前沿领域和现状,提出了目前各种合成方法存在的不足和缺陷。最后,在课题组研究工作的基础上,提出了合成此类化合物的研究前景和展望。Benzoxazole and benzothiazole,which are common and important substructures in pharmaceuticals,pesticides,natural products and biologically active molecules,are widely used in organic synthesis and concerned by many researchers. The synthesis of benzoxazole and benzothiazol by intermolecular condensation reactions and intramolecular condensation reactions currently were described. The deficiencies and shortcomings of the existing synthesis methods were also described. Finally,the research prospects and expectation for the synthesis of benzoxazole and benzothiazole were proposed based on our previous work.

关 键 词：苯并噁唑 苯并噻唑 合成方法 

分 类 号：O626.2[理学—有机化学]