糖尿病前期患者内脏脂肪面积与脂肪因子的相关性研究  

Correlation between visceral fat area and adipocytokines in prediabetic patients

作　　者：余劲明[1] 黄建皓[1] 玉颜庆[1] 张文娇[1] 颜晓东[1] 

机构地区：[1]广西壮族自治区人民医院内分泌科,南宁530021

出　　处：《中国临床新医学》2016年第11期971-974,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西医疗卫生重点科研课题(编号:重2012108)

摘　　要：目的探讨糖尿病前期患者内脏脂肪面积(VATA)与血清脂肪因子的相关性。方法选择在该院门诊确诊的糖尿病前期患者57例,其中超重组22例,肥胖组14例(P-NGT),正常体重组21例。检测其血清胰岛素(FINS)、脂联素(APN)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)水平,按稳态模型计算胰岛素抵抗指数(HOMA-IR),采用双能X线骨密度仪检测观察对象全身脂肪比例及VATA。结果 (1)超重及肥胖组血清FINS、HOMA-IR及TNF-α水平明显高于正常体重组(P<0.01);APN水平明显低于正常体重组(P<0.01)。IL-6在三组之间差异无统计学意义。(2)肥胖组的全身脂肪比例明显高于超重组及正常体重组(P<0.01);肥胖组及超重组VATA均显著高于正常体重组(均P<0.01);(3)APN与腰臀比(WHR)、HOMA-IR、全身体脂比例、VATA、甘油三酯(TG)呈负相关;TNF-α与WHR、HOMA-IR、全身体脂比例、VATA、TG呈正相关。结论糖尿病前期超重及肥胖患者VATA明显增加,与APN分泌减少密切相关,可能是糖代谢紊乱的重要影响因素。Objective To investigate the correlations between visceral fat area and adipocytokines in prediabetic patients. Methods Fifty-seven prediabetic patients were collected from outpatient visit and divided into 3groups： the obesity group（ n = 14）,the overweight group（ n = 22）,and normal weight group（ n = 21）. The levels of serum FINS,APN,TNF-α and IL-6 were detected. The homeostasis model assessment of insulin resistance（ HOMAIR） was used as a parameter to evaluate the degrees of insulin resistance. Total body fat percentage and visceral adipose tissue area（ VATA） were assessed using dual emission X-ray absorptiometry. Results（ 1） The levels of serum FINS,HOMA-IR and TNF-α were significantly higher in both the overweight group and the obesity group than in the normal weight group. The levels of APN were significantly lower in the overweight group and the obesity group than in the normal weight group. There were no significant differences in the levels of serum IL-6 among the three groups.（ 2） The total body fat percentage in the obesity group was significantly higher than that of the overweight group or the normal weight group. There were no differences in total body fat percentage between the overweight group and the normal weight group. Visceral adipose tissue area in the obesity group or the overweight group was significantly higher than that in the normal weight group.（ 3） APN was negatively correlated with FINS,WHR,HOMA-IR,VATA,total body fat percentage and TG,whereas TNF-α was positively correlated with FINS,WHR,HOMA-IR,VATA,TG and total body fat percentage. Conclusion VATA is significantly increased in the overweight and obese prediabetic patients,which is relate to the decrease secretion of APN and the cause of disorder glucose metabolisms.

关 键 词：糖尿病前期 内脏脂肪面积 脂肪因子 脂联素 

分 类 号：R587.1[医药卫生—内分泌]