ICP-MS法测定抗病毒口服液9种元素含量及其质量评价  

Determination of Nine Elements in Kangbingdu Oral Liquid by ICP-MS and its Quality Assessment

作　　者：陈桂茜 周玲娜 梅新路[2] 龚琴丹 

机构地区：[1]浙江金华市食品药品检验检测研究院,金华321000 [2]浙江金华市中心医院,金华321000 [3]浙江金华市婺城区食品药品监督管理局,金华321000

出　　处：《海峡药学》2016年第11期56-58,共3页Strait Pharmaceutical Journal

摘　　要：目的 建立电感耦合等离子体质谱法（ICP-MS）测定抗病毒口服液中铅、镉、砷、汞、铜、铬、镍、铝、镁9种元素含量的方法并对其进行质量评价。方法 样品经微波消解系统消解完全后,采用ICP-MS进行含量测定,对9种元素的量进行控制。结果 测定5个不同厂家的7批抗病毒口服液,所测元素线性关系良好（r〉0.9992）,加样回收率在90.0~105.9%之间,检出限0.006~0.105ng·m L-1;精密度RSD为1.5%~3.0%。结论 抗病毒口服液中砷镁铝含量较高,需要生产厂家在购进原料及生产过程中予以足够重视。OBJECTIVE To establish an ICP-MS method for the determination of Pb, Cd, As, Hg, Cu, Cr, Ni, Al and Mg in Kangbingdu oral liquid and evalute it on quality. METHODS The samples were digested by microwave digestion system fully and detected by ICP-MS. RESULTS By testing the samples of seven batches from five different manufactures, the results showed the determined method has good linear relationship （ correlation 〉 0. 9992）. The sample average recovery was 90. 0 - 105.9%. The detection limits of the method were 0. 006 -0. 105ng . mL-1. The RSDs of introduction precision were 1.5% - 3.0%. CONCLUSION The contents of arsenic, magnersium, almihum in Kangbingdu oral liquid was so high that manufacturers need to pay more attention in the process of purchasing raw materials and production.

关 键 词：抗病毒口服液 电感耦合等离子体质谱 重金属 质量评价 

分 类 号：R927[医药卫生—药学]