普拉洛芬联合玻璃酸钠治疗干眼症的疗效观察  

Observation of the Curative Effect of Pranoprofen Combined with Sodium Hyaluronate in the Treatment of Xerophthalmia

作　　者：徐涛[1] 

机构地区：[1]浙江省嘉兴市第二医院眼科,嘉兴314000

出　　处：《海峡药学》2016年第11期87-89,共3页Strait Pharmaceutical Journal

摘　　要：目的 探讨普拉洛芬联合玻璃酸钠滴眼液治疗干眼症的临床疗效。方法 选取2015年8月~2016年5月我院就诊的108例干眼症患者,随机分为研究组与对照组,每组54例。对照组单纯给予玻璃酸钠滴眼液,1日4次,1次1滴;研究组在对照组基础上给予普拉洛芬滴眼液,1日4次,1次1滴。2周后比较两组患者泪液分泌试验（SchirmerⅠ）、泪膜破裂时间（BUT）、角膜不规则性参数（SRI、SAI）指标,评价两组患者临床治疗效果。结果 治疗2周后,研究组BUT显著高于对照组（P〈0.05）,SRI、SAI显著低于对照组（P〈0.05）。研究组总有效率为92.59%,显著高于对照组的75.93%（P〈0.05）。结论 对于干眼症患者,普拉洛芬与玻璃酸钠联合治疗能够改善眼部干涩症状,延缓泪膜破裂时间,疗效确切,值得推广。OBJECTIVE To explore the clinical curative effect of pranoprofen combined with sodium hyaluronate eye drops in the treatment of xerophthalmia. METHODS From August 2015 to May 2016 in our hospital, 108 patients with xerophthalmia were tested and observed. In accordance with the number table, patients were divided into two groups,54 cases in each group. The control group only received sodium hyaluronate eye drops. On the basis of control group, the research group received the treatment of pranoprofen eye drops. Compare two groups of patients with Schirmer Ⅰ , BUT, SRI, SAI after two weeks. Evaluation of clinical therapeutic effects of two groups of patients. RESULTS After treatment for 2 weeks, the research group＇s BUT was significant higher than the control group＇s （ P 〈 0. 05 ）, SRI, SAI was significant lower than the control group （ P 〈 0. 05 ）. The research group＇s total ef- fective rate was 92. 59% , obviously higher than the control group＇s 75.93% （P 〈 0. 05 ）. CONCLUSION Pranoprofen eye drops combined with sodium hyaluronate eye drops in the treatment of xerophthalmia can improve the symptoms of xerophthalmia, delay the tear break-up time, worthy of clinical popularization and application. It wasworth clinical promoting.

关 键 词：普拉洛芬滴眼液 玻璃酸钠滴眼液 干眼症 

分 类 号：R969.4[医药卫生—药理学]