^(14)C尿素呼气试验与蛋白芯片抗体对比研究  

Comparative study of 14C urea breath test and antibody protein chip

作　　者：吴友根[1] 王平[1] 杨忠[1] 陈大勇[1] 罗春梅[1] 刘红兵[1] 罗菊华[1] 李朝金[1] 唐兴俊[1] 

机构地区：[1]中国十九冶集团有限公司职工医院(攀枝花市第六人民医院),四川攀枝花617023

出　　处：《齐齐哈尔医学院学报》2016年第24期3013-3014,共2页Journal of Qiqihar Medical University

基　　金：攀枝花市适宜卫生技术研究(2015CY-S-29)

摘　　要：目的探索^(14)C尿素呼气试验(UBT)和蛋白芯片抗体(CagA、VacA和Ure)检测诊断Hp感染中的价值。方法 230例患者分别进行^(14)C-UBT和蛋白芯片抗体检测,对结果进行分析。结果 230例患者^(14)C-UBT测定阳性总数100例,阳性率43.4%,^(14)C-UBT阳性患者蛋白芯片抗体阳性总数38例,阳性率38%。230例蛋白芯片抗体阳性总数77例,阳性率33.5%,蛋白芯片抗体阳性患者的^(14)C-UBT阳性数36例,阳性率46.7%。结论本组患者的蛋白芯片抗体、^(14)C呼气试验阳性率低于我国幽门螺旋杆菌平均感染率,说明以上两种方法用于诊断Hp感染的敏感性有待提高。Objective To explore 14C urea breath test （^14 C-UBT） with Helicobacter pylori （Hp） antibody protein chip （CagA, VacA and Ure ） in diagnosis of gastric Hp infection in value. Methods 230 patients were detected by 14C-UBT and antibody protein chip, comparing the results of 2 groups.Results 230 cases of patients with 14C-UBT in determination of the total number of positive for 100 cases, the positive rate of 43.4%, 14C-UBT positive patients with protein chip antibody positive for a total of 38 cases, positive rate 38%. 230 cases of protein chip antibody positive total to 77 cases, positive rate was 33.5%, protein chip anti positive patients with 14C-UBT positive for 36 cases. The positive rate was 46.7%. Conclusions The positive rate of Hp antibody protein chip and laC-UBT in this group of patients, is significantly lower than China average infection rate of Hp, which illustrates that the sensitivity of the above two methods for the diagnosis of Hp infection needs to be improved.

关 键 词：幽门螺杆菌 14C尿素呼气试验 感染 蛋白芯片抗体 

分 类 号：R378[医药卫生—病原生物学]