眼部弓形虫感染的病理生理学和诊断  

Pathophysiology and diagnosis of ocular toxoplasmosis

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作  者:周苗苗[1] 石磊[2] 高惠中[3] 文继月[4] 

机构地区:[1]皖西卫生职业学院,安徽237000 [2]安徽医科大学附属省立医院 [3]武警后勤学院学员二旅 [4]安徽医科大学基础医学院药理研究室

出  处:《齐齐哈尔医学院学报》2016年第24期3080-3082,共3页Journal of Qiqihar Medical University

摘  要:弓形虫是一种常见寄生虫,感染全世界大约三分之一的人口,它的传播途径广泛,可通过先天或后天感染,主要寄生在眼内组织,引起眼弓形虫感染后的持久性病变(OT)。虽然人类在眼弓形虫的研究上已经取得一些成就,但是了解这种疾病的流行病学意义和病理损害对疾病的诊断治疗是非常有意义的。特别是在疾病症状体征不典型情况下通过生物学方法进行早期诊断对于预防不可逆病变甚至失明是非常有意义的。本综述集中有关眼弓形虫病理生理和微生物诊断方法最新进展,给临床医生提供有价值的诊断方法和依据。Toxoplasma gondii is a ubiquitous obligate intracellular parasite which infects approximately one third of the human population worldwide. Despite the route of transmission, congenital or acquired routes, this parasite has a post-infection persistence mainly in ocular tissues which causes ocular toxoplasmosis (OT). Although, important advances have been achieved in understanding the epidemiology and pathophysiology of this potentially blinding disease; the damage caused by this parasite on the human eye and its functioning remains important. Therefore, early diagnosis of OT plays a major role in the patient's management, especially in atypical cases, and the prevention of irreversible lesions and blindness. This review will focus on recent advances in pathophysiology of OT and microbiological tools available to the clinician that allows its diagnosis.

关 键 词:眼弓形虫 生物学诊断 葡萄膜炎 诊断 

分 类 号:R531.8[医药卫生—内科学]

 

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