双歧杆菌三联活菌对婴儿胆汁淤积性肝病患儿肝功能的影响  

Influence of triple viable bifidobacterium on liver functions in infants with cholestatic hepatopathy

作　　者：李红[1,2] 鄢素琪[2] 王芳[2] 万琦[2] 

机构地区：[1]湖北中医药大学,湖北武汉430065 [2]武汉市妇女儿童医疗保健中心,湖北武汉430016

出　　处：《中国医院药学杂志》2016年第22期1996-1998,共3页Chinese Journal of Hospital Pharmacy

基　　金：武汉市科学技术计划(编号:2013062301010807)

摘　　要：目的:观察双歧杆菌三联活菌治疗婴儿胆汁淤积性肝病(ICH)患儿的临床疗效。方法:将临床诊断为ICH的104例患儿按随机数字表法分为治疗组及对照组。两组均给予必要的抗感染、抗病毒及保肝利胆等常规综合治疗,治疗组在此基础上加用双歧杆菌三联活菌,0.5 g/次,每日3次。两组疗程均为2周。对两组临床疗效及肝功能相关指标进行比较分析。结果:治疗组总有效率为84.62%,对照组总有效率为67.31%,两组总有效率的比较,差异有统计学意义(P<0.05)。与对照组相比,治疗组治疗后总胆红素(Tbil)、直接胆红素(Dbil)、总胆汁酸(TBA)显著降低,差异有统计学意义(P<0.01)。而谷丙转氨酶(ALT)、白蛋白(ALB)虽有不同程度改善,但差异无统计学意义(P>0.05)。结论:双歧杆菌三联活菌能调节肠道菌群失调,有助于ICH患儿临床症状体征的改善及肝功能的恢复。OBJECTIVE To observe curative effects of triple viable bifidobacterium in infants with cholestatic hepatopathy. METHODS A total of 104 cases of infantile cholestatic hepatopathy were randomly divided into treatment group （TG） and control group（CG）. Patients in both groups were given conventional comprehensive treatment composed of antibiotics, antivi- rals, glucurolactone, inosine and ursodeoxycholic acid. Triple viable bifidobacterium was given to TG patients additionally. The treatment lasted for 2 weeks. Curative effects were compared between two groups. RESULTS Total effective rate in TG （84. 62%） was higher than that in CG （67. 31%） （P〈0. 05）. Compared with CG, there was significant decrease in TG after treatment inTbil, Dbil and TBA （P〈0. 01）. Despite improvements in ALT and ALB to a certain extent, the difference was not statistically significant （P〉0. 05）. CONCLUSION Triple viable bifidobacterium can regulate intestinal flora imbalance. It does good to improvement of clinical symptoms and signs and recovery of liver functions.

关 键 词：肠道菌群 双歧杆菌三联活菌 婴儿胆汁淤积性肝病 

分 类 号：R969[医药卫生—药理学]