抗菌药物应用和血液病患者真菌性肠炎的相关性  

Relationship between application of antimicrobial agents and fungal enteritis in patients with blood diseases

作　　者：孙海燕[1] 张雷[1] 赵泉[1] 曲淑君 

机构地区：[1]烟台毓璜顶医院,山东烟台264000 [2]烟台市烟台山医院,山东烟台264000

出　　处：《中国医院药学杂志》2016年第22期1999-2001,共3页Chinese Journal of Hospital Pharmacy

基　　金：烟台市科技发展计划项目(编号:2012069)

摘　　要：目的:探讨抗菌药物的应用和血液病患者继发真菌性肠炎的相关性。方法:对2010-2014年血液病科继发真菌性肠炎的住院患者与同期住院的非真菌性肠炎患者抗菌药物应用进行回顾性调查与统计学分析。结果:共确诊60例真菌性肠炎患者,平均年龄(52.43±27.00)岁,真菌性肠炎组使用抗菌药物平均(15.83±8.02)d出现真菌感染,与非真菌性肠炎组有显著性差异;抗菌药物的使用比例和联合应用也远大于非真菌性肠炎组,有显著性差异;导致真菌性肠炎的抗菌药物主要集中在加酶抑制剂、喹诺酮类、林可霉素类和碳青霉烯类。结论:继发真菌性肠炎与抗菌药物的联合使用、时间长短和抗菌药物的品种有关。OBJECtIVE To study the relationship between application of antimicrobials and fungal enteritis in patients with blood diseases. METHODS Secondary fungal enteritis was retrospectively investigated and statistically analyzed from 2010 to 2014 in hospitalized patients with blood diseases. RESULTS Sixty patients had fungal enteritis, with a mean age of （52. 43 ±27. 00） years. Fungal infections were observed in the fungal enteritis group with an average of （15.83 ± 8. 02） days. Statistical- ly significant difference was observed between fungal enteritis group and non-fungal enteritis group in medication time, ratio of antimicrobial and combined medication. The antibacterial drugs with enzyme inhibitors, quinolones, lineomycin and carbopene- ms might induce fungal enteritis. CONCLUSION Some correlation exists between fungal enteritis and combined medication, medication time and variety of antimicrobial agents.

关 键 词：抗菌药物 真菌性肠炎 相关性 

分 类 号：R969[医药卫生—药理学]