三维超声心动图评价早衰症儿童左心室收缩功能  

Evaluation of left ventricular systolic function in Hutchinson-Gilford progeria syndrome children by three- dimensional echocardiography

作　　者：赵晓妮[1] 杨帆[1] 马慧[1] 宋宏萍[1] 郑敏娟[1] 朱永胜[1] 刘丽文[1] 孙新[2] 刘宝华[3] 

机构地区：[1]第四军医大学西京医院超声科,西安710032 [2]第四军医大学西京医院儿科,西安710032 [3]香港大学医学院

出　　处：《中华超声影像学杂志》2016年第11期921-925,共5页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金（81301228）

摘　　要：目的应用三维超声心动图技术评估早衰症儿童左-12,室收缩功能。方法6例确诊早衰症儿童、21例正常儿童和14例衰老程度相当的健康老年人均行三维超声心动图检查。存储图像导入TomTec4DLV-Analysis软件分析，获得左室舒张末期容积（LVEDV）、收缩末期内径（LVESV）、射血分数（LVEF）、，12,肌质量（Mass）、整体纵向应变（GLS）、整体圆周应变（GCS）、左室扭转（Twist）、扭矩（Torsion）、平均达峰时间、收缩不同步指数（SDI）等数据。将三组测量结果进行比较分析。结果①左室功能：早衰症儿童组、正常儿童组LVEDD均小于老年组（P〈0．05），而早衰症儿童组、正常儿童组间差异无统计学意义（P〉0．05）；早衰症儿童组LVESD、LVEDV、LVESV、Mass较正常儿童组、老年组明显减低（P〈0．05）；早衰症儿童组、正常儿童组LVEF值均大于老年组（P〈0．05）。②左室应变：早衰症儿童组和正常儿童组GLS值均高于老年组（P〈0．05），但早衰症儿童组和正常儿童组GLS值差异无统计学意义（P〉0．05）；早衰症儿童组GCS值与其他两对照组比较差异均无统计学意义（P〉0．05），正常儿童组高于老年组（P〈0．05）；三组Twist、Torsion比较差异均无统计学意义（P〉0．05）。③左室运动协调性：早衰症儿童组各节段平均达峰时间最低，且正常儿童组低于老年组（P〈0．05）；SDI值早衰症儿童组和正常儿童组均低于老年组（P〈0．05），而早衰症儿童组和正常儿童组差异无统计学意义（P〉0．05）。结论早衰症儿童左室功能虽存在一定程度改变，但可能与真正的衰老改变模式不同，仍需进一步解读探究。Objective To investigate the left ventricular （LV） function in Hutchinson-Gilford progeria syndrome（HGPS） children by three-dimensional echocardiography. Methods Six HGPS children, 21 age-matched children, and 14 senescence-matched healthy volunteers were examined by three-dimensional echocardiography. Image data were collected and analyzed by TomTec 4D LV-Analysis software. LV end- diastolic and end-systolic volume （LVEDV, LVESV）, ejection fraction （LVEF）, mass, global longitudinal strain （GLS）, global circumferential strain （GCS）, twist, torsion, mean time to peak, systolic dyssynchrony index （SDI） were calculated and analyzed. Results ①Cardiac function： compared with age-matched children and senescence-matched healthy volunteers, LVEDD showed no significant difference, LVESD, LVEDV, LVESV and mass of HGPS children were significant impaired than those of age-matched children and senescence-matched healthy volunteers （ P〈0.05） ;LVEF in HGPS children and age-matched children were significant higher than that in senescence-matched healthy volunteers（ P d0.05）.②Strain analysis： GLS of HGPS children and age-matched children were significant higher than that of senescence-matched healthy volunteers（ P d0.05）, there was no significant difference between HGPS children and age-matched children. GCS of HGPS children showed no significant differences with age-matched children and senescence-matched healthy volunteers. Torsion and twist among three groups showed no significant difference. ③LV synchrony： compared with age-matched children and senescence-matched healthy volunteers, the mean time to peak in HGPS children was significantly reduced （ P〈0.05）. The SDI values in the HGPS children and age-matched children were significantly lower than that of senescence-matched healthy volunteers （P〈0.05）, while HGPS children and age-matched children showed no significant difference（ P〈0.05）. Conclusions LV dyssynchrony is not showed in HGPS but does in senesc

关 键 词：超声心动描记术 实时三维 早衰症 心室功能 左 应变 

分 类 号：R540.45[医药卫生—心血管疾病] R725.9[医药卫生—内科学]