准静态弹性成像与剪切波弹性成像评价兔肝消融灶的实验研究  

Evaluation for real-time elastography versus shear wave elastography on the ablation zone of rabbit liver： a preliminary experimental study

作　　者：徐明[1] 林满霞[1] 庄博文 苏丽娅[1] 李晓菊[1] 刘保娴 田文硕[1] 刘明[1] 谢晓燕[1] 吕明德[2] 

机构地区：[1]中山大学附属第一医院超声科,广州510080 [2]中山大学附属第一医院肝胆外科,广州510080

出　　处：《中华超声影像学杂志》2016年第11期990-995,共6页Chinese Journal of Ultrasonography

基　　金：国家自然科学基金重点项目（81530055）

摘　　要：目的比较准静态弹性成像及剪切波弹性成像在兔肝消融灶评估及弹性测量中的作用。方法采用Cool—Tip射频针分别在10只新西兰大白兔肝脏建立消融灶。消融后采用准静态弹性成像及剪切波弹性成像方法对消融灶进行弹性检测，并分别进行超声造影检查，分析两种弹性成像方法检测的消融灶弹性值；将其所测得的消融灶面积进行比较，并分别与造影图像及大体标本所测消融灶面积进行比较。结果准静态弹性成像与剪切波弹性成像均可在术后清晰显示消融灶范围。准静态弹性成像测得消融灶与周边肝脏的弹性比值为3．22±0．70；剪切波弹性成像显示消融灶中央至边缘的弹性杨氏模量值逐渐降低，消融灶处杨氏模量值为（51．1±11．5）kPa，但消融灶边缘处为（29．70±3．28）kPa。准静态弹性成像与剪切波弹性成像显示消融灶面积分别为（1．087±0．179）cm^2、（1．058±0．219）cm^2，差异无统计学意义（P=0．534）。弹性测量消融灶面积与大体标本面积（1．044±0．194）cm^2比较差异无统计学意义（P〉0．05）。超声造影显示消融灶呈均匀无增强，其所测量消融灶面积（2．882±0．796）cm^2，明显大于大体标本及弹性测量的面积（P〈0.05）。结论准静态弹性成像及剪切波弹性成像都可于术后短时间内较准确地确定消融灶范围；剪切波成像对消融边缘的定量测量为将来临床应用中确定消融边界具有指导意义。Objective To comparatively evaluate the ablation zone of rabbit liver with real-time elastography （RTE） and shear wave elastography （SWE）. Methods A unipolar internal cooled radiofrequency probe was used to form the ablation zone for ten rabbit liver. After the ablation, RTE and SWE were used to measure the value of elastography. Contrast enhanced ultrasound was also used to assess the ablation zone. The value of elastography from these two methods and the scope of ablation zone among the CEUS images, samples and elastography images were compared, respectively. Results RTE and SWE could display the scope of ablation zone just after the ablation. RTE image could get the ratio of the ablation zone and the surrounding liver which was 3.22±0.70. SWE could display the value of elasticity decreased from the center to the edge of ablation zone. The value of elasticity for the center and the rim of ablation zone were （51.1±11.5）kPa and （29.70±3.28）kPa. The area of ablation zone for RTE and SWE were （1.087±0. 179）cm^2 and （1. 058±0.219）cm^2. There were no difference in the ablation area among RTE, SWE and the gross specimen （ P〉0.05）. CEUS displayed non-enhancement for ablation zone, but the area of ablation zone was larger than those from gross sample （ P〈0.05）. Conclusions RTE and SWE could confirm the scope of ablation zone. And the SWE provides the guidance for confirming the boundary of ablation zone for the future clinical application.

关 键 词：准静态弹性成像 剪切波弹性成像 射频消融术 肝 

分 类 号：R445.1[医药卫生—影像医学与核医学] R735.7[医药卫生—诊断学]