探讨阿托品联合长托宁在不同治疗时机对重度急性有机磷农药中毒的治疗效果  

Explore the therapeutic effect of atropine combined with penehyclidine hydrochloride in the treatment of severe acute organophosphorus pesticide poisoning

作　　者：张建东[1] 龙雄[1] 单立兵[1] 舒啸[1] 

机构地区：[1]南方医科大学附属小榄医院急诊科,广东510515

出　　处：《齐齐哈尔医学院学报》2016年第25期3163-3164,共2页Journal of Qiqihar Medical University

摘　　要：目的探讨阿托品联合长托宁不同时机治疗重度急性有机磷农药中度的临床疗效。方法筛选本院收治的重度急性有机磷农药中毒患者80例作为研究对象。随机分为观察组与对照组,每组40例,对照组在开始抢救时便采用阿托品联合长托宁,观察组则先用阿托品达到阿托品化后,再联用长托宁治疗,比较两组治疗效果以及临床结局。结果观察组患者阿托品化时间、胆碱酯酶活力恢复50%时间、住院时间明显小于对照组,P<0.05;观察组患者中毒反跳、阿托品中毒发生率明显低于对照组,P<0.05。结论首先阿托品快速达到阿托品化,在联用小剂量长托宁以及阿托品维持阿托品化状态治疗重度急性有机磷农药中毒较传统直接联用药物可有效提升临床治疗效果,具有临床应用及推广价值。Objective To investigate the clinical efficacy of penehyclidine hydrochloride combined with atropine in the treatment of severe acute organic phosphorus pesticide moderate at different time. Methods Screening 80 cases of patients admitted to our hospital with severe acute organophosphorus pesticide poisoning as the research objects. They were randomly divided into observation group and control group,40 cases in each group. The patients in control group at the beginning of the rescue were penehyclidine hydrochloride combined with atropine. the observation group was given atropine to reach atropinization, and then combined with penehyclidine hydrochloride for treatment. Prognosis and therapeutic effect was compared between the two groups.Results The time of atropinization,cholinesterase activity recovery of 50% and length of hospital stay in observation group was significantly less than that of the control group,P〈0. 05. Conclusions First use atropine to quickly reach atropinization,in combination with small dose of penehyclidine hydrochloride in the treatment of severe acute obtain better efficacy than combination use directly.Worth of clinical use and promotion.

关 键 词：阿托品 长托宁 应用时机 重度急性有机磷农药中毒 临床疗效 

分 类 号：R595.4[医药卫生—内科学]