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作 者:张军霞[1] 林红军[1] 张婷婷[1] 陈炜[1] 李振国[1] 周继春[1]
出 处:《中国药房》2016年第34期4774-4776,共3页China Pharmacy
基 金:河南省科技创新人才计划项目(No.144200510028)
摘 要:目的:研究益气活血风静胶囊对麻醉犬脑血流量(CBF)及脑血管阻力(CVR)的影响,为其临床应用提供药理学依据。方法:将18只Beagle犬随机分为假手术组(纯化水)、阳性对照中药组[脑心通胶囊,0.3 g(生药)/kg]、阳性对照化学药组(尼莫地平,7×10^(-3)g/kg)和益气活血风静胶囊高、中、低剂量组[2.52、1.26、0.63 g(生药)/kg)],每组3只。犬麻醉后十二指肠给药,分别于给药前和给药30、60、120 min后测定血压、心率和CBF、CVR的变化。结果:给药30、60、120 min后,阳性对照中药组、阳性对照化学药组和益气活血风静胶囊高剂量组犬CBF明显增加,阳性对照化学药组和益气活血风静胶囊高剂量组犬CVR明显减小,阳性对照化学药组犬血压和心率降低,与假手术组比较差异均有统计学意义(P<0.05或P<0.01)。结论:益气活血风静胶囊可减小麻醉犬CVR、增加CBF,对血压及心率无影响。OBJECTIVE:To observe the effects of Yiqi huoxue fengjing capsules on the cerebral blood flow(CBF)and cerebral vascular resistance(CVR) in anesthetized dogs.METHODS:18 Beagle dogs were randomly divided into sham operation group(purified water),positive control TCM group [Naoxintong capsules,0.3 g(crude drug)/kg],positive control pharmaceutical chemicals group(nimodipine,7 × 10-3g/kg) and Yiqi huoxue fengjing capsules low-dose,medium-dose and high-dose groups[0.63,1.26,2.52 g(crude drug)/kg)],with 3 dogs in each group.They were given relevant medicine via duodenum.CBF,CVR,blood pressure and heart rate of the dogs were measured before medication and 30,60,120 min after medication.RESULTS:30,60,120 min after medication,CBF increased in positive control TCM group,positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsule high-dose group,while CVR decreased significantly in positive control pharmaceutical chemicals group and Yiqi huoxue fengjing capsules high-dose group,blood pressure and heart rate of positive control pharmaceutical chemicals group decreased,with statistical significance compared to sham operation group(P〈0.05 or P〈0.01).CONCLUSIONS:Yiqi huoxue fengjing capsules can increase CBF and decrease CVR,and they have no effect on blood pressure and heart rate in anesthetized dogs.
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