醋酸亮丙瑞林微球治疗子宫内膜异位症效果研究  

Effect of leuprorelin acetate microspheres in the treatment of endometriosis

作　　者：李妮[1] 李花繁 李维玲[1] 李雪绒[1] 

机构地区：[1]西安高新医院产三科,西安710075

出　　处：《中国性科学》2016年第11期32-35,共4页Chinese Journal of Human Sexuality

摘　　要：目的:观察醋酸亮丙瑞林微球治疗子宫内膜异位症的效果及对患者CA125水平的影响,旨在为子宫内膜异位症患者术后选择巩固药物治疗提供科学依据。方法:选取子宫内膜异位症患者86例作为研究对象。均经腹腔镜术后病理组织学确诊,随机分为实验组和对照组,每组各43例。实验组给予醋酸亮丙瑞林微球治疗。对照组给予口服避孕药达英-35治疗。观察并比较两组患者的疗效及药物不良反应的发生情况,测定患者外周血CA125水平。结果:两组患者的总有效率无统计学差异(P>0.05)。停药后6个月,实验组无复发,对照组出现4例复发,复发率有统计学差异(P<0.05)。治疗前,两组患者的CA125水平无统计学差异,治疗后,两组患者的CA125均较治疗前降低,差异有统计学意义(P<0.05)。治疗前,实验组与对照组患者性激素水平无统计学差异(P>0.05),治疗后,实验组与对照组患者性激素水平均较治疗前降低,且实验组水平均低于对照组,差异有统计学意义(P<0.01)。两组之间的不良反应发生率无统计学差异(P>0.05)。结论:醋酸亮丙瑞林微球治疗子宫内膜异位症的疗效确切,复发率低,可降低血清CA125水平以阻滞疾病进展,虽有部分不良反应,但多为低雌激素症状,且程度较轻,可进一步临床推广。Objectives： To observe the effect of leuprolide acetate microspheres in the treatment of endometriosis and its effect on CA125 level of patients so as to provide scientific reference for those with endometriosis after surgery. Methods： 86 patients with endometriosis were selected as research objects. All of these patients received laparoscopic postoperative pathological diagnosis and were randomly divided into experimental group and control group,with 43 cases in each group. The experimental group was given Leuprolide Acetate Microspheres for treatment,whereas the control group was given oral contraceptive Diane-35 for treatment. The curative effect and incidence of adverse reactions were observed and compared between two groups. The level of CA125 in peripheral blood was detected. Results： There was no statistically significant difference in total efficiency between two groups（ P〉0. 05）. Six months after treatment,no recurrence was found in experimental group,yet 4 cases of recurrence were found in control group,with statistically significant difference（ P〈0. 05）. Before treatment,no statistically significant difference was found in the aspect of CA125 level. After treatment,CA125 levels in both groups were lower than these before treatment,with statistically significant difference（ P〈0. 05）. Before treatment,there was no statistically significant difference found in sex hormone level between two groups（ P〉0. 05）. After treatment,sex hormone level in both groups decreased. And sex hormone level of experimental group was lower than that of control group,with statistically significant difference（ P〈0. 01）. There was no significant difference shown in the incidence of adverse reactions between two groups（ P〉0. 05）. Conclusion： Leuprolide acetate microsphere is with definite effect in the treatment of endometriosis,with low recurrence rate. It can reduce the patients＇ serum CA125 level. Although there are some adverse reactions accompanied,the main manifestation is low e

关 键 词：醋酸亮丙瑞林微球 子宫内膜异位症 复发率 避孕药 继发性痛经 

分 类 号：R711.71[医药卫生—妇产科学]