不明原因不孕患者黄体期补充雌激素的意义分析  

Significance of estrogen supplementation in the corpus phase of unexplained infertility

作　　者：权效珍[1] 覃小敏[1] 刘韵[1] 朱艳[1] 杨学舟[1] 

机构地区：[1]湖北文理学院附属襄阳市中心医院妇产科,湖北襄阳441021

出　　处：《中国性科学》2016年第11期94-96,共3页Chinese Journal of Human Sexuality

基　　金：湖北省自然科学基金资助项目(2014CFB251);湖北省襄阳市科技计划研究与开发项目(Zd201303)

摘　　要：目的:分析探讨黄体期添加雌激素对不明原因不孕患者的影响,为改进临床方案提供一定的理论依据。方法:选取2011年1月至2015年1月于我院就诊的不明原因不孕患者41例与正常生育妇女60例为研究对象,对比分析各组雌、孕激素水平及比例分布差异。将不孕组雌激素低下患者分为对照组和实验组,两组均给予孕激素(P)治疗,实验组在此基础上于黄体期加用雌激素(E2),对比分析治疗效果的改善情况。结果:不孕组患者排卵后第7d的P、E2及P/E2比值明显低于正常组,两组比较差异具有统计学意义(P<0.05),而排卵后第3d各组指标无统计学差异(P>0.05);在不孕患者中,加用E2、P治疗的实验组,排卵后第7d治疗组患者的P及P/E2比值改善情况明显优于单用P的对照组(P<0.05),排卵后第3d各组指标比较不具有统计学差异(P>0.05);实验组妊娠成功率分别明显高于对照组(P<0.05)。结论:黄体期添加雌激素可提高不明原因不孕患者的妊娠成功率,为临床上不明原因不孕患者的预防和治疗提供新思路,具有进一步扩大研究的价值。Objectives： To investigate the significance of estrogen supplementation in the corpus phase of unexplained infertility so as to provide a theoretical basis for improving the clinical program. Methods： 41 unexplained infertility patients and 60 normal reproductive women in our hospital from January 2011 to January 2015 were selected for the study. Comparative analysis was done on estrogen and progesterone levels and proportion differences of distribution. Patients with low estrogen in infertility group were divided into control and experimental groups. Two groups were given progesterone（ P） treatment. The experimental group was given estrogen（ E2） in the luteal phase. Therapeutic effects of two groups were compared. Results： 7 days after ovulation,P,E2 and P/E2 ratio of infertile patients was significantly lower than these of normal group,with statistically significant difference（ P〈0. 05）. Three days after ovulation,the indexes of each group showed no statistically significant difference（ P〉0. 05）; among infertility patients,seven days after ovulation,P and P/E2 ratio improvement of experimental group was significantly better than that of control group（ P〈0. 05）. Three days after ovulation,the indexes of two groups did not have a statistically significant difference（ P〉0. 05）; the pregnancy success rate of experimental group were significantly higher（ P〈0. 05）. Conclusion： Estrogen supplementation in the corpus phase can increase the success rate of pregnancy with unexplained infertility,which provides new ideas for unexplained infertility prevention and treatment,with a further expansion of research value.

关 键 词：不明原因不孕 黄体期 雌激素 妊娠率 

分 类 号：R711.6[医药卫生—妇产科学]