囊胚和卵裂期胚胎玻璃化冷冻解冻移植周期的妊娠结果分析  

Pregnancy results of blastocysts and cleavage stage embryo after thawing in transfer cycles

作　　者：罗清炳[1] 徐鸿毅[1] 张鑫[1] 李欣[1] 张昌军[1] 

机构地区：[1]湖北医药学院附属人民医院生殖医学研究中心,湖北十堰442000

出　　处：《中国性科学》2016年第11期100-102,共3页Chinese Journal of Human Sexuality

摘　　要：目的:比较囊胚和卵裂期胚胎玻璃化冷冻解冻后移植周期的妊娠结果。方法:回顾分析2014年1月至2014年12月在我院生殖医学中心行玻璃化冷冻解冻移植周期388个患者的妊娠情况,其中囊胚冷冻解冻165个移植周期(A组),卵裂期胚胎冷冻解冻223个移植周期(B组)。结果:A组和B组解冻存活率分别98.76%和96.74%,两组间无统计学差异(P>0.05);临床妊娠率、种植率和单胎率A组(68.48%、57.38%和76.10%)显著高于B组(68.48%、57.38%和59.37%);多胎率、双胎率和三胎率A组(23.01%、22.12%和0.88%)显著低于B组(40.62%、31.25%和9.37%,P<0.05);A组和B组的流产率分别为5.31%和6.25%,两组间无统计学差异。结论:囊胚和卵裂期胚胎玻璃化冷冻解冻均能获得较高的存活率、临床妊娠率和种植率,且囊胚玻璃化冷冻移植周期提高了临床妊娠率及种植率,同时降低了多胎率的发生。Objectives： To investigate pregnancy results of blastocysts and cleavage stage embryo after thawing in transfer cycle. Methods： Retrospective analysis was done on the pregnancy outcome of 388 patients who were treated with embryo tranfer after thawing in our hospital reproductive medical center from January 2014 to December 2014. They were divided into two groups including 165 cases of blastocyst transfer cycle（ A group） and 223 cases of cleavage stage embryo cycles（ B group）. The clinical pregnancy rate,implantation rate and multiple pregnancy rate were compared. Results： Embryo survival rate of group A and group B were 98. 76% and 96. 74% respectively and there was no significant difference between two groups（ P〉0. 05）; Clinical pregnancy rate,implantation rate and single embryo rate in group A（ 68. 48%,57. 38% and 76. 10%） were higher than these of group B（ 68. 48%,57. 38% and 59. 37%）; multiple pregnancy rate,twins rate and triplets rate in group A（ 23. 01%,22. 12% and 0. 88%） were lower than these of group B（ 40. 62%,31. 25% and 9. 37%,P〈0. 05）; abortion rate of group A and group B were respectively 5. 31% and 6. 25%,and the difference was not statistically significant. Conclusion： The vitrification cryopreservation of blastocysts and cleavage stage embryo after thawing relatively had higher survival rate,clinical pregnancy rate and implantation rate. The vitrification cryopreservation of blastocysts can improve clinical pregnancy rate and reduce superfoetation rate occurrence.

关 键 词：玻璃化冷冻 囊胚 胚胎 妊娠率 

分 类 号：R711.6[医药卫生—妇产科学]