铝佐剂的作用机制研究进展  

Update of mechanisms of action for aluminum-based adjuvants

作　　者：闻晓波[1] 张玲玲[1] 冉旭华[1] 

机构地区：[1]黑龙江八一农垦大学动物科技学院,黑龙江大庆163319

出　　处：《现代畜牧兽医》2016年第11期47-52,共6页Modern Journal of Animal Husbandry and Veterinary Medicine

基　　金：黑龙江省自然科学基金(QC2013C028;C2015042);国家自然科学青年基金项目(31502098;31201909);国家自然科学基金国际(地区)合作与交流项目(31310103031)

摘　　要：随着亚单位疫苗、合成肽疫苗等新型疫苗的出现,免疫佐剂的研究也逐渐得到人们关注,铝佐剂作为唯一被应用于人用疫苗的佐剂,其作用机制尚未完全明确。随着研究的深入,早期的部分理论也面临诸多质疑。本文结合近年来对铝佐剂自身性质、作用机制等研究数据进行论述,以求促进对铝佐剂作用机制的深入了解和应用。With the development of subunit vaccines, synthetic peptide vaccines and other noval vaccines, the varied adjuvants, including aluminum-based adjuvant, are required to modulate po- tent and desired immune response. However, mechanism of action for aluminum-based adjuvants, which can exclusively used in human world wide, is still not fully understood. This review mainly focuses on the relationship between characterisation of aluminum-based adjuvant and mechanism based on the recent data, in an attempt to facilitate the understanding and utilization of alumi- num-based adjuvant in the generation of noval vaccines.

关 键 词：佐剂 铝佐剂 作用机制 联合佐剂 纳米颗粒 

分 类 号：R392[医药卫生—免疫学]