人工授精术后14天血清人绒毛膜促性腺激素及倍增水平对妊娠结局的预测意义  

Significance of serum β-hCG and multiplication level after 14 days of artificial insemination in prediction of pregnancy outcome

作　　者：彭璇[1] 倪金莲[1] 梅园园[1] 温国亮[1] 

机构地区：[1]九江市妇幼保健院辅助生殖科,江西九江332000

出　　处：《中国妇幼保健》2016年第23期5102-5104,共3页Maternal and Child Health Care of China

基　　金：江西省卫生厅科技计划课题(2015115)

摘　　要：目的探讨人工授精术后14天妊娠者血清人绒毛膜促性腺激素(β-hCG)及倍增水平对妊娠结局的预测意义。方法收集该院2005年7月-2015年10月人工授精术后255个妊娠周期的资料,回顾性分析术后14 d的血清β-hCG及倍增水平与妊娠结局的关系。根据最终随访结果分为不良妊娠和继续妊娠。不良妊娠:生化妊娠组(A组)、异位妊娠组(B组)、早期妊娠流产组(C组);继续妊娠:宫内妊娠单胎组(D组)及宫内妊娠双胎组(E组)。结果术后14 d的血清β-hCG:A组(80.5±22.1)mIU/ml;B组(135.3±80.4)mIU/ml;C组(200.1±100.4)mIU/ml;D组(320.5±160.7)mIU/ml;E组(700.4±200.8)mIU/ml。不良妊娠组术后14 d、16 d血清β-hCG低于继续妊娠组(P<0.05),血清β-hCG比值低于继续妊娠组(P<0.05)。结论血清β-hCG及倍增水平是预测人工授精术后妊娠结局的有效方法,可早期发现病理妊娠,改善预后。Objective To explore the significance of serum β-human chorionic gonadotrophin （β-hCG） and multiplication level after 14 days of ariificial insemination in prediction of pregnancy outcome. Methods The data of 255 pregnancy cycles after artificial insemination were collected from the hospital from July 2005 to October 2015, the relationships between serum β-hCG, multiplication level ＂after 14 days of artificial insemination and pregnancy outcome were analyzed retrospectively, the cases with adverse pregnancy were divided into group A （biochemical pregnancy group）, group B （ectopic pregnancy group）, and group C （early pregnancy abortion group） ; the cases with continued pregnancy were divided into group D （single birth intrauterine pregnancy group） and group E （twin intrauterine pregnancy group） . Results The levels of serum β-hCG after 14 days of artificial insemination in group A, group B, group C, group D, and group E were （80. 5±22. 1 ） mIU/ml, （135.3±80.4） mIU/ml, （200. 1 ±100.4） mIU/ml, （ 320. 5±160.7 ） mIU/ml, and （700.4±200. 8 ） mIU/ml, respectively. The levels of serum β-hCG after 14 and 16 days of artificial insemination and serum β-hCG ratio in adverse pregnancy group were statistically significantly lower than those in continued pregnancy group （ P〈0. 05 ） . Conclusion Serum β-hCG and multiplication level are effective methods to predict pregnancy outcome after artificial insemination, which can early find pathological pregnancy and improve prognosis.

关 键 词：人工授精 血清人绒毛膜促性腺激素 倍增水平 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]