空气及尿液中硬金属及其化合物测定的电感耦合等离子体质谱法  

Determination of relative elements of hard metal in workplace air and urine by inductive coupled plama

作　　者：李西西[1] 焦燕妮[3] 罗英男 陈艳霞 田东[5] 娄峰[6] 李厚达[6] 李蔚[3] 陈金东[3] 闫永建[1] 

机构地区：[1]山东省职业卫生与职业病防治研究院,济南250062 [2]济南大学山东省医学科学院医学与生命科学学院 [3]山东省疾病预防控制中心 [4]青岛中心医疗集团 [5]淄博市职业病防治院 [6]中国石化青岛安全工程研究院

出　　处：《中华劳动卫生职业病杂志》2016年第11期861-864,共4页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：卫生公益性行业科研专项（201402021）;卫生部卫生监督中心卫生标准研制与应用项目（20140712）;山东省自然科学基金（ZR2015YL044）

摘　　要：目的利用电感耦合等离子体质谱法（ICP-MS）建立工作场所空气和人体尿中铬、钨、钴、镍、镉、锰、铅及其化合物的快速检测方法。方法采集空气及尿液样本，运用ICP-MS进行测定，对方法的检出限、准确度、精密度及稳定性进行评价，并采用滤膜及尿冻干金属标准物质对方法的准确度进行验证。结果待测元素铬、钨、钴、镍、镉、锰、铅在实验选定的范围内具有良好的线性关系，相关系数均大于0．999，空气样本加标回收率为91．6％～104．6％，批内精密度为1．41％～3．50％，批间精密度为1．28％～4．31％；尿样加标回收率为93．0％～102．6％，批内精密度为1．25％～3．56％，批间精密度为1．58％～4．67％，标准物质尿样中铬、镉及滤膜中铅、镉、锰的测定结果均在参考值范围内。结论ICP．MS法快速准确简便，可用于职业接触硬金属粉尘作业工人尿样中硬金属及其化合物及工作场所空气中硬金属及其化合物的定量检测。Objective To establish a rapid detection method regarding the air conditions of workplace and the workers＇ urine included Tungsten , Cobalt , Nickel , Titanium, Cadmium , Manganese, Lead and its compounds based on inductively coupled plasma mass spectrometry （ICP-MS）. Methods The experiment adopts ICP-MS to determine those metals in workshop air and workers urine, evaluate the detection＇s limitation, the precision and accuracy of the method. Using the membrane filter and urine freeze-dried metal standard material to verify this method. Results Each element of correlation coefficient was greater than 0.999. The recovery rate of air samples was 91.6%-104.6%, within-batch RSD precision was 1.41%-3.50%, between-run precision was 1.28%-4.31%, urine samples recovery rate was 93.0%-102.6%, within-batch RSD precision was 1.25%- 3.56%, between-run precision was 1.58%-4.67%, According to the method every element was within the scope of the standard reference, it was also showed that the established method is accurate and reliable. Conclusion ICP-MS is an effective and feasible method to detect the workshop air and the workers＇ urine which included Tungsten , Cobalt , Nickel , Titanium, Cadmium , Manganese, Lead and its compounds.

关 键 词：镍 钴 钨 镉 空气 电感耦合等离子体质谱 

分 类 号：R134.4[医药卫生—劳动卫生]