归芍六君子汤治疗结直肠癌患者癌因性疲劳的临床观察  

Clinical Observation on Guishao Liujunzi Decoction in the Treatment of Cancer-Related Fatigue of Colorectal Cancer Patients

作　　者：王蕾[1] 谢智惠[2] 肖寒[3] 吕庆[2] 

机构地区：[1]江南大学附属医院中医科,无锡214062 [2]江南大学附属医院普外科,无锡214062 [3]江南大学附属医院中西医结合肿瘤科,无锡214062

出　　处：《中国中医药现代远程教育》2016年第21期70-73,共4页Chinese Medicine Modern Distance Education of China

基　　金：江苏省无锡市医管中心项目(No:ygzx1219)

摘　　要：目的观察加减归芍六君子汤治疗Ⅱ~Ⅲ期直肠癌患者癌因性疲劳的临床疗效。方法应用随机平行对照方法,将60例符合癌因性疲劳诊断的结直肠癌患者,随机分为2组。对照组30例患者使用对症治疗;治疗组30例患者使用治疗并服用加减归芍六君子汤,1日2次口服,15天为1个疗程,治疗2个疗程。其间间隔5日,2组均观察2个疗程。均行手术根治术,术后化疗方案采用肠癌NCCN的Capox 21天的标准化疗方案。观察比较疲劳症状评分、临床疗效、骨髓抑制情况、细胞免疫功能相关指标。结果经过2个疗程治疗后,治疗组疲劳评分均数较对照组下降明显,差异具有统计学意义(P<0.05),且两组治疗前后比较差异有统计学意义(P<0.05);治疗组临床有效率为76.6%;对照组有效率为40%,差异具有统计学意义(P<0.05)。治疗组白细胞、血红蛋白计数升高,明显高于对照组白细胞及血红蛋白计数,差异具有统计学意义(P<0.05)。两组患者血小板计数在治疗前及治疗后改变均不明显。对照组患者的CD^+3,CD^+4,CD^+4/CD^+8水平明显下降,而治疗组患者的CD^+3,CD^+4,CD^+4/CD^+8的水平较化疗前有所提高,差异具有统计学意义(P<0.05),且两组组间同期比较亦有统计学差异(P<0.05);比较NK细胞,治疗组百分比有所下降,但两组间无统计学意义。结论说明使用加减归芍六君子汤能较好改善结直肠癌患者癌因性疲劳的诸多症状,同时可增强其免疫功能,从而提高患者生活质量。Objective To observe the clinical effect of modified Guishao Liujunzi decoction in the treatment of cancer-related fatigue（CRF） of colorectal cancer patients in Ⅱ- Ⅲ period. Methods 60 cases of CRF of colorectal cancer patients were randomly divided into two groups. The control group of 30 patients was treated with conventional support. The treatment group of 30 patients was given routine therapy and modified Guishao Liujunzi decoction, 2 times a day for 15 days for a period of treatment, even served two course of treatment, and the two courses had 5 days interval. In the two groups, they were observed 2 course of treatment. Two groups of patients were performed radical surgery, postoperative chemotherapy regimens with colorectal NCCN Capox 21 days as a course of standard chemotherapy regimens. The fatigue symptom scores, clinical efficacy, bone marrow suppression, lymphocyte immune function related indicators were compared. Results After two courses of treatment, the fatigue rating mean of the treatment group decreased significantly comparing with control group, and the difference was statistically significant（P〈0.05）, and differences between the two ways also had statistical significance（P〈0.05）. The clinical effective rate of the treatment group was 76.6%, the effective rate of the control group was 40%, and the difference statistically significant（P〈0.05）. The treatment group was obviously higher than that of control group in white blood cells and hemoglobin count, and there was statistically significant difference（P〈0.05）. Two groups of patients with platelet count change in both before and after treatment were not obvious. The control group of patients with CD^＋3, CD^＋4,CD^＋4 / CD^＋8 level declined obviously, and the treatment group of patients with CD^＋3, CD^＋4, CD^＋4 / CD^＋8 levels increased before chemotherapy, and there was statistical difference（P〈0.05）. At the same time, the difference between two ways was also statistically significant（P〈0.05�

关 键 词：癌因性疲劳 中医药疗法 归芍六君子汤 直肠癌 

分 类 号：R273[医药卫生—中西医结合]