结核灵片联合化疗对初治菌阳肺结核病有效性及安全性评价  

Evaluation on the Effectiveness and Safety of Jieheling Tablets combined with Chemotherapy in the Treatment of Primary Smear-positive Pulmonary Tuberculosis

作　　者：张爽 

机构地区：[1]辽宁省锦州市传染病医院药剂科,锦州121017

出　　处：《中国中医药现代远程教育》2016年第21期75-76,共2页Chinese Medicine Modern Distance Education of China

摘　　要：目的探究对初治菌阳肺结核病实施结核灵片联合化疗治疗的有效性与安全性。方法选取2014年1月—2015年12月收治的78例初治菌阳肺结核患者作为研究对象,随机分成两组,观察组40例,对照组38例。观察组患者接受抗结核化疗药方案治疗,对照组患者接受单纯抗结核化疗药治疗。观察对比两组患者临床疗效、痰菌转阴情况、病灶吸收情况分析。结果 2月末、6月末时,观察组治疗总有效率均明显优于对照组(P<0.05),2组对比存在显著统计学差异,可见观察组临床症状改善均明显较对照组优良(P<0.05)。2月末、6月末时,观察组痰菌阴转率均明显较对照组优良(P<0.05)。2月末、6月末两组患者病灶吸收总有效率对比均存在显著统计学差异,观察组胸CT显示疗效明显较对照组患者优良(P<0.05)。结论结核灵片联合化疗对初治菌阳肺结核病临床疗效显著,临床有效性较高,可有效改善临床症状,病灶吸收率较高,无严重不良反应,安全性较高,值得临床推广。Objective To explore the effectiveness and safety of Jieheling tablets combined with chemotherapy in the treatment of prima-ry smear-positive pulmonary tuberculosis. Methods Selecting 78 cases of primary smear-positive pulmonary tuberculosis in our hospital from January 2014 to December 2015 were selected as the research objects, they were randomly divided into observation group of 40 cases and control group of 38 cases. The observation group was given Jieheling tablets combined with chemotherapy treatment. Patients in the control group were treated with chemotherapy alone. The clinical curative effect, negative sputum analysis and absorption of le-sions of the patients were compared between the two groups. Results At the end of two months and the end of six months, the sputum negative conversion rate of the observation group was significantly better than that of the control group（ P〈0.05）. There were significant differences in the total effective rate of the two groups of patients, comparing with the control group, the curative effect of CT in the ob-servation group was better than that in the control group（P〈0.05）. The incidence of adverse reactions in the observation group was sig-nificantly lower than that in the control group（P〈0.05）. Conclusion Jieheling tablets combined with chemotherapy in the treatment of primary smear-positive pulmonary tuberculosis has significantly clinical effect, can effectively improve the clinical symptoms, and has higher absorption of lesions rate, no serious adverse reactions and high security, and is worthy of clinical promotion.

关 键 词：初治菌阳肺结核病 结核灵片 化疗 有效性 安全性 肺痨 

分 类 号：R521[医药卫生—内科学]