紫檀芪对肠缺血再灌注损伤的保护作用和机制研究  

The Protective Effect and Mechanism of Pterostilbene on Intestinal Ischemia Reperfusion Injury

作　　者：孙洋[1] 常青[1] 崔岚[1] 

机构地区：[1]黑龙江省医院麻醉科,黑龙江哈尔滨150001

出　　处：《中国卫生标准管理》2016年第20期193-195,共3页China Health Standard Management

摘　　要：目的本研究拟通过建立肠缺血再灌注动物模型,分析紫檀芪对肠缺血再灌注损伤的作用和相关机制。方法选用雄性健康清洁级Wistar大鼠,随机分四组,造模通过无创小动脉夹夹闭肠系膜上动脉30 min,再灌注24 h。取肠组织切片进行HE染色和光镜观察肠组织损伤。结果应用紫檀芪预先作用,其肠组织结构损伤明显减轻。结论本研究证实紫檀芪预处理肠缺血再灌注可减轻肠组织的病理损伤,为治疗药物提供参考依据。为进一步深入研究对肠缺血再灌注损伤的保护作用和机制提出理论基础。Objective This study was to establish an animal model of intestinal ischemia-reperfusion,to analyze the role of pterostilbene on intestinal ischemiareperfusion injury and its mechanism. Methods Healthy male Wistar rats of clean grade were randomly divided into four groups,casting small noninvasive artery by clamping the superior mesenteric artery 30 min,reperfusion 24 h. Taking intestinal tissue sections for HE staining and light microscopy of intestinal tissue damage. Results Apply the pterostilbene in advance,significantly reduced intestinal tissue structural damage. Conclusion This study demonstrated pterostilbene preconditioning can reduce intestinal ischemia-reperfusion injury in intestinal tissue pathology,and to provide a basis for treatment. For further study of the protective effect and mechanism of intestinal ischemia-reperfusion injury presented theoretical basis.

关 键 词：紫檀芪 肠缺血再灌注 病理损伤 

分 类 号：R285.5[医药卫生—中药学]