不同剂量的地佐辛对预防女性丙泊酚注射痛的随机对照研究  

Randomized Controlled Trial: Prevention of Propofol Injection Pain by Different Doses of Dezocine in Women

作　　者：柏满云[1] 廖琴[1] 赵倩[2] 彭毅梅[2] 张晓青[2] 李玉芳[2] 

机构地区：[1]中南大学湘雅三医院麻醉科,湖南长沙410013 [2]长沙市第四医院麻醉科,湖南长沙410006

出　　处：《现代生物医学进展》2016年第33期6445-6447,6435,共4页Progress in Modern Biomedicine

摘　　要：目的:观察预注不同剂量的地佐辛在预防女性丙泊酚注射痛中的镇痛效应,寻找地佐辛的适宜剂量。方法:本研究为随机对照研究,选择ASAⅠ-Ⅱ级行择期宫腔镜手术的女性患者200例,采用计算机随机数字法分为四组。C组(n=39):预先注射生理盐水;D1组(n=50):预先注射地佐辛0.025 mg/kg;D2组(n=55):预先注射地佐辛0.05 mg/kg;D3组(n=56):预先注射地佐辛0.1mg/kg,所有预注药物均稀释至5 m L,注药时间均为10 s,并于注药后2 min采用TCI泵1 m L/s的速度推注2 mg/kg丙泊酚。记录患者预注药物前后SBP、DBP、HR、Sp O_2及不良反应;注射丙泊酚的过程中反复询问疼痛情况,采用Ambesh四点评分法行注射疼痛评分。结果:D2组、D3组丙泊酚注射痛发生率均显著低于C组(P<0.05),D1组与C组比较无统计学差异(P>0.05),D2组与D3组比较无统计学差异(P>0.05)。D3组眩晕、嗜睡的发生率明显高于D1组和D2组(P<0.05)。结论:地佐辛能有效降低女性丙泊酚注射痛的发生率和严重程度,降低注射痛的适宜剂量为0.05 mg/kg。Objective： To observe the effects of prophylactic intravenous administration of dezocine against propofol injection pain in women in order to find the suitable dose of dezocine. Methods： In this randomized controlled study, 200 female patients（ASAⅠ-Ⅱ）who accepted hysteroscopy surgery with general anesthesia were randomly divided into four groups according to the computer random number method. Before anesthesia induction, preliminary injection of experimental drug was performed as follows： the control group： physiological saline 5 m L, D1 group： 0.025 mg/kg of dezocine, D2 group： 0.05 mg/kg of dezocine, D3 group： 0.1 mg/kg of dezocine, group. The injection time was 10 s. 2 min after preliminary injection, 2 mg/kg propofol was pumped with the speed of 1 m L/s and the pain score was evaluated by Ambesh four score. HR, SBP, DBP, Sp O2 and other adverse reactions was observed and recorded at different time points. The initial dose and total amount of propofol was recorded. Results： There was no statistically significance between group D1 and C（P〉0.05）, while the incidence of propofol injection pain in group D2 and D3 all was significantly lower than that in group C（P〈0.05）; there were no statistically significance between group D2 and D3（P〉0.05）. The incidence of vertigo and somnolence was significantly higher in group D3 than that in group C, D1 and D2（P〈0.05）. Conclusions： Dezocine can significantly reduce the incidence of propofol injection pain in women, and the suitable dose of dezocine is 0.05 mg/kg.

关 键 词：地佐辛 丙泊酚注射痛 女性 

分 类 号：R713[医药卫生—妇产科学] R614[医药卫生—临床医学]