二甲双胍联合西格列汀对2型糖尿病患者氧化应激、胰岛素抵抗的影响  

Effects of Metformin combined with Pioglitazone on Oxidative Stress and Insulin Resistance in Patients with Type 2 Diabetes Mellitus

作　　者：郝姝[1] 贾真[1] 张渭涛[1] 王颖[1] 姚孝礼[2] 何旺[1] 

机构地区：[1]西安市第一医院内分泌科,陕西西安710002 [2]西安交通大学第一附属医院内分泌科,陕西西安710061

出　　处：《现代生物医学进展》2016年第33期6467-6469,6525,共4页Progress in Modern Biomedicine

基　　金：陕西省自然科学基金项目(03043719)

摘　　要：目的:探讨二甲双胍联合西格列汀对2型糖尿病患者氧化应激、胰岛素抵抗的影响。方法:收集我院就诊或住院治疗的80例2型糖尿病患者,随机分为实验组和对照组,每组40例。两组患者入院后均给予相应的治疗措施,对照组患者给予二甲双胍250 mg/次,2次/d;实验组患者在对照组的基础上给予西格列汀100 mg/次,1次/d,治疗均连续8周。治疗结束后对患者血清丙二醛(MDA)、8异前列腺素F2α(8-iso-PGF2α)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)以及患者临床治疗效果进行检测并比较。结果:与治疗前相比,治疗后两组患者MDA、8-iso-PGF2α、FBG、FINS以及HOMA-IR水平均下降(P<0.05);与对照组相比,实验组患者MDA、8-iso-PGF2α、FBG、FINS以及HOMA-IR水平较低(P<0.05),临床治疗总有效率较高(P<0.05)。结论:二甲双胍联合西格列汀能够降低2型糖尿病患者血糖水平,降低MDA、8-iso-PGF2α水平,减轻氧化应激反应,降低胰岛素抵抗,临床疗效较好。Objective： To investigate the effect of metformin combined with pioglitazone on the oxidative stress and insulin resistance in patients with type 2 diabetes mellitus. Methods： 80 patients with type 2 diabetes mellitus were selected and randomly divided into experiment group and control group with 40 cases in each group. After admission, the patients in the two groups were given corresponding treatment measures, while the control group was treated with metformin 250 mg/time, twice daily, and the patients in the experimental group were given sitagliptin 100 mg / time, once a day on the basis of the control group, respectively for 8 weeks. After the end of the treatment, the serum level of malondialdehyde（MDA）, 8 ISO prostaglandin F2 alpha（8-iso-pgf2α）, fasting blood glucose（FBG）, fasting insulin（FINS）, insulin resistance index（HOMA-IR） and the clinical efficacy were detected and compared. Results： Compared with before treatment, the MDA, 8-iso-pgf2α, FBG, fins and HOMA-IR levels were decreased after treatment in the two groups of patients（P〈0.05）; compared with the control group, the MDA, 8-iso-pgf2α, FBG, fins and HOMA-IR levels were lower（P〈0.05）, the total effective rate was higher（P〈0.05） in the experimental group. Conclusions： The combination of metformin and pioglitazone has good clinical effect in treatment of type 2 diabetes mellitus, it can reduce the blood glucose and MDA and 8-iso-PGF2 level, alleviate oxidative stress and insulin resistance.

关 键 词：二甲双胍 西格列汀 2型糖尿病 氧化应激 胰岛素抵抗 

分 类 号：R587.1[医药卫生—内分泌]