Protein self-assembly: technology and strategy  

作　　者：Linlu Zhao Shanpeng Qiao Junqiu Liu 

机构地区：[1]State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University

出　　处：《Science China Chemistry》2016年第12期1531-1540,共10页中国科学（化学英文版）

基　　金：supported by the National Natural Science Foundation of China(21234004,21420102007,21574056,91527302);the Chang Jiang Scholars Program of China

摘　　要：Proteins, as the premier building blocks in nature, exhibit extraordinary ability in life activities during which process proteins mostly self-assemble into large complexes to exert prominent functions. Inspired by this, recent chemical and biological stud- ies mainly focus on supramolecular self-assembly of proteins into high ordered architectures, especially the assembly suategy to unravel tile formation and function of protein nanostructures. In this review, we st, mmarize the progress made in the engi- neering of supramolecular protein architectures according to the strategies used to control the orient：ilion and the order of the assembly process. Furthermore, potential applications in biomedical areas of the supramolecular protein nanostructures will also be reviewed.Proteins, as the premier building blocks in nature, exhibit extraordinary ability in life activities during which process proteins mostly self-assemble into large complexes to exert prominent functions. Inspired by this, recent chemical and biological studies mainly focus on supramolecular self-assembly of proteins into high ordered architectures, especially the assembly strategy to unravel the formation and function of protein nanostructures. In this review, we summarize the progress made in the engineering of supramolecular protein architectures according to the strategies used to control the orientation and the order of the assembly process. Furthermore, potential applications in biomedical areas of the supramolecular protein nanostructures will also be reviewed.

关 键 词：protein assembly supramolecular strategy SELF-ASSEMBLY electrostatic interaction metal-ligand coordination 

分 类 号：O629.73[理学—有机化学]